Quaderi N A, Meehan R R, Tate P H, Cross S H, Bird A P, Chatterjee A, Herman G E, Brown S D
Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom.
Genomics. 1994 Aug;22(3):648-51. doi: 10.1006/geno.1994.1442.
The methyl CpG binding proteins (MeCP1 and MeCP2) are a class of proteins that bind to templates containing symmetrically methylated CpGs. Using an interspecific backcross segregating a number of X-linked markers, we have localized the Mecp2 gene in mouse to the X chromosome close to the microsatellite marker DXMit1. Detailed physical mapping utilizing an available YAC contig encompassing the DXMit1 locus has localized the Mecp2 gene to a 40-kb region between the L1cam and the Rsvp loci, indicating the probable position of a homologue on the human X chromosome.
甲基化CpG结合蛋白（MeCP1和MeCP2）是一类与含有对称甲基化CpG的模板结合的蛋白质。利用分离多个X连锁标记的种间回交，我们已将小鼠中的Mecp2基因定位到靠近微卫星标记DXMit1的X染色体上。利用包含DXMit1位点的现有YAC重叠群进行的详细物理图谱分析已将Mecp2基因定位到L1cam和Rsvp位点之间的一个40 kb区域，这表明了人类X染色体上同源物的可能位置。
