Adler D A, Quaderi N A, Brown S D, Chapman V M, Moore J, Tate P, Disteche C M
Department of Pathology, University of Washington, Seattle 98195, USA.
Mamm Genome. 1995 Aug;6(8):491-2. doi: 10.1007/BF00356163.
DNA methylation at the promoter region of X-linked genes is associated with the maintenance of X inactivation in mammals. One of the methylated DNA binding proteins, MECP2, that binds to methylated bases in DNA is encoded by a gene (Mecp2) located on the mouse X Chromosome (Chr). To determine whether this gene was expressed from the inactive X Chr, and X-autosome translocation (T(X;16)16H) system in which expression from the Mecp2 allele on the inactive X Chr could be assayed was used. Results from these experiments indicate that Mecp2 is subject to X inactivation in mouse.
X连锁基因启动子区域的DNA甲基化与哺乳动物X染色体失活的维持有关。一种与DNA中甲基化碱基结合的甲基化DNA结合蛋白MECP2，由位于小鼠X染色体（Chr）上的一个基因（Mecp2）编码。为了确定该基因是否从失活的X Chr表达，使用了X-常染色体易位（T(X;16)16H）系统，在该系统中可以检测失活X Chr上Mecp2等位基因的表达。这些实验结果表明，Mecp2在小鼠中会发生X染色体失活。
