Sørensen J L, Thranov I, Hoff G, Dirach J
Dept. of Gynecology and Obstetrics, Rigshospitalet, Copenhagen O.
Infection. 1994 Jul-Aug;22(4):242-6. doi: 10.1007/BF01739907.
After termination of a double-blind, randomized study on erythromycin in the prevention of post-abortion infection, 34 women (14 treated with erythromycin, 20 not treated with erythromycin) harbouring Chlamydia trachomatis were followed up within 6 weeks and again 2 to 24 months after the abortion in order to detect an early- and late-onset pelvic inflammatory disease (PID). For statistical analysis survival analysis by Kaplan-Meir estimates and Mantel-Cox test were carried out. Untreated women with C. trachomatis infection at the time of abortion had a cumulative risk of 72% of developing early and/or late PID, if observed for 24 months. This cumulative risk was significantly reduced to 8% if the C. trachomatis infection was treated at the time of the abortion. Screening for and treatment of C. trachomatis is warranted, especially in women < or = 25 years old, to avoid early and late-onset PID after induced first trimester abortion.
在一项关于红霉素预防流产后感染的双盲随机研究结束后，对34名携带沙眼衣原体的女性（14名接受红霉素治疗，20名未接受红霉素治疗）在流产后6周内进行了随访，并在流产后2至24个月再次随访，以检测早发性和迟发性盆腔炎（PID）。为进行统计分析，采用Kaplan-Meir估计法和Mantel-Cox检验进行生存分析。流产时未治疗的沙眼衣原体感染女性，如果观察24个月，发生早发性和/或迟发性PID的累积风险为72%。如果在流产时对沙眼衣原体感染进行治疗，该累积风险可显著降低至8%。有必要对沙眼衣原体进行筛查和治疗，尤其是对年龄≤25岁的女性，以避免在孕早期人工流产后发生早发性和迟发性PID。
