Harshfield G A, Pulliam D A, Alpert B S
Department of Pediatrics, University of Tennessee, Memphis.
Am J Hypertens. 1994 Mar;7(3):282-5. doi: 10.1093/ajh/7.3.282.
Our previous studies using noninvasive ambulatory blood pressure (ABP) monitoring demonstrated racial differences in the diurnal pattern of blood pressure (BP), with higher nighttime BP for African-Americans than for Anglo-Americans despite similar daytime BP. We have hypothesized that the increased BP load in African-Americans contributes to the increased prevalence of hypertension and BP-induced target organ damage in adults. The purpose of this study was to examine the relationship between ABP patterns and renal function in healthy, normotensive black and white youths. The subjects were 22 African-American and 28 Anglo-American children and adolescents aged 10 to 18 years. Renal function was estimated by creatinine clearance (CCr). The African-American and Anglo-American subjects were similar in age, gender composition, casual BP, and CCr. The relationship between CCr and BP was not significant for casual BP or daytime BP for either group, or with nighttime BP in the Anglo-American subjects. In contrast, CCr was related negatively to both nighttime systolic BP (r = -0.47, beta = -1.21; P < .02) and nighttime diastolic BP in the African-American subjects (r = -0.45, beta = -2.13; P < .03). These results are consistent with our hypothesis.
我们之前使用无创动态血压（ABP）监测的研究表明，血压（BP）的昼夜模式存在种族差异，尽管白天血压相似，但非裔美国人的夜间血压高于英裔美国人。我们推测，非裔美国人血压负荷增加导致成年人高血压患病率上升以及血压引起的靶器官损害增加。本研究的目的是检验健康、血压正常的黑人和白人青年中ABP模式与肾功能之间的关系。研究对象为22名非裔美国儿童和青少年以及28名10至18岁的英裔美国儿童和青少年。通过肌酐清除率（CCr）评估肾功能。非裔美国人和英裔美国人在年龄、性别构成、偶测血压和CCr方面相似。两组的偶测血压或白天血压以及英裔美国人的夜间血压与CCr之间的关系均不显著。相比之下，非裔美国人的CCr与夜间收缩压（r = -0.47，β = -1.21；P < .02）和夜间舒张压均呈负相关（r = -0.45，β = -2.13；P < .03）。这些结果与我们的假设一致。
