Keegan A, Batey R
Department of Medicine, Westmead Hospital, New South Wales, Australia.
J Gastroenterol Hepatol. 1994 Mar-Apr;9(2):205-6. doi: 10.1111/j.1440-1746.1994.tb01245.x.
Under normal circumstances the rate of hepatic ethanol oxidation and the rate at which ethanol is removed from the blood are dependent on the hepatic activity of alcohol dehydrogenase. It is possible that ethanol metabolism, and thus hepatic alcohol dehydrogenase, could influence ethanol consumption. In this study 11 adult female Wistar rats were provided with 20% ethanol as their sole drinking fluid and ethanol consumption was measured. After a further period of drinking tap water, the hepatic alcohol dehydrogenase activity was determined. A significant inverse relationship was found between the ethanol consumption by the rats and the hepatic activity of alcohol dehydrogenase (P < 0.05). This enzyme could therefore play a role in determining the amount of alcohol an animal will consume.
在正常情况下，肝脏乙醇氧化速率以及乙醇从血液中清除的速率取决于酒精脱氢酶的肝脏活性。乙醇代谢以及肝脏酒精脱氢酶有可能会影响乙醇的摄入量。在本研究中，给11只成年雌性Wistar大鼠提供20%的乙醇作为它们唯一的饮用水，并测量乙醇摄入量。在进一步饮用自来水一段时间后，测定肝脏酒精脱氢酶活性。发现大鼠的乙醇摄入量与肝脏酒精脱氢酶活性之间存在显著的负相关关系（P < 0.05）。因此，这种酶可能在决定动物的酒精摄入量方面发挥作用。
