Keegan A, Batey R
Department of Gastroenterology, Westmead Hospital, New South Wales, Australia.
Alcohol Clin Exp Res. 1993 Apr;17(2):431-3. doi: 10.1111/j.1530-0277.1993.tb00789.x.
In naive animals the rate of ethanol elimination is dependent on the hepatic alcohol dehydrogenase activity. Carbohydrates have been shown to modify ethanol metabolism by a mechanism that has not been determined. In this study, adult female rats, fed chow diets supplemented with fructose or glucose in their drinking water for 10 days demonstrated significantly greater ethanol elimination rates (4.85 +/- 0.28 and 4.92 +/- 1.56 microM ethanol/min/g liver, respectively) than rats receiving water (3.65 +/- 0.29). The hepatic alcohol dehydrogenase activity of the fructose (1687 +/- 101 nM ethanol/min/g liver) and the glucose (1832 +/- 15)-supplemented rats were not significantly different from that of control rats (1845 +/- 160). Dietary carbohydrate supplementation, therefore, enhanced ethanol elimination, but did not alter the activity of alcohol dehydrogenase. Thus the changes in the ethanol elimination rate following carbohydrate loading were not the consequence of an alteration in hepatic alcohol dehydrogenase.
在未接触过乙醇的动物中，乙醇的消除速率取决于肝脏乙醇脱氢酶的活性。碳水化合物已被证明可通过一种尚未明确的机制来改变乙醇代谢。在本研究中，成年雌性大鼠饮用添加果糖或葡萄糖的饲料10天，其乙醇消除速率（分别为4.85±0.28和4.92±1.56微摩尔乙醇/分钟/克肝脏）显著高于饮用纯水的大鼠（3.65±0.29）。补充果糖（1687±101纳摩尔乙醇/分钟/克肝脏）和葡萄糖（1832±15）的大鼠肝脏乙醇脱氢酶活性与对照大鼠（18,45±160）无显著差异。因此，膳食补充碳水化合物可增强乙醇消除，但不会改变乙醇脱氢酶的活性。所以，碳水化合物负荷后乙醇消除速率的变化并非肝脏乙醇脱氢酶改变的结果。
