Rohlmann A, Laskawi R, Hofer A, Dermietzel R, Wolff J R
Department of Anatomy, University of Göttingen, Germany.
Neuroreport. 1994 Jan 12;5(4):409-12. doi: 10.1097/00001756-199401120-00009.
Facial nerve transection leads to functional and structural reactions in lesioned motor neurones and surrounding glial cells. Data from this study provide evidence that the most rapid reaction described so far consists of an increase in immunoreactivity of connexin-43 (cx-43), the predominant gap junction protein in astrocytes. The ipsilateral facial nucleus is selectively marked as early as 0.75 to 1.5 hours after axotomy, while the unlesioned side as well as the unoperated controls remain faintly stained. Thus, enhanced coupling capacity of astrocytes by gap junctions appears to be a sensitive indicator of modified neuronal-glial interaction in the CNS.
面神经横断会导致受损运动神经元和周围神经胶质细胞发生功能和结构反应。本研究数据表明，迄今为止所描述的最快速反应包括连接蛋白43（cx - 43）免疫反应性增加，cx - 43是星形胶质细胞中主要的间隙连接蛋白。在轴突切断后最早0.75至1.5小时，同侧面神经核就被选择性标记，而未受损侧以及未手术的对照组则染色较浅。因此，间隙连接增强星形胶质细胞的耦联能力似乎是中枢神经系统中神经元 - 神经胶质相互作用改变的一个敏感指标。
