Rohlmann A, Laskawi R, Hofer A, Dobo E, Dermietzel R, Wolff J R
Department of Anatomy, Developmental Neurobiology, University of Göttingen, FRG.
Neurosci Lett. 1993 May 14;154(1-2):206-8. doi: 10.1016/0304-3940(93)90208-3.
After peripheral transection of the facial nerve, immunostaining of astrocytic gap junction protein changed in the corresponding brainstem nucleus of the rat. Enhanced connexin-43 immunoreactivity was restricted to the ipsilateral facial nucleus and to astrocytes surrounding lesioned motoneurons. This reaction is focally distinct, and marks only a part of the astrocytic network indicating a local plasticity of intercellular coupling. These results suggest that astrocytes work as sensors of signals which either depend on the integrity of neighboring neurons or inform about neuronal disorders.
面神经周围横断后，大鼠相应脑干核中星形胶质细胞间隙连接蛋白的免疫染色发生变化。连接蛋白43免疫反应性增强仅限于同侧面神经核和损伤运动神经元周围的星形胶质细胞。这种反应在局部是明显的，仅标记星形胶质细胞网络的一部分，表明细胞间偶联具有局部可塑性。这些结果表明，星形胶质细胞作为信号传感器，要么依赖于相邻神经元的完整性，要么传递有关神经元紊乱的信息。
