Wolf R, Brenner S
Department of Dermatology, Tel-Aviv Sourasky Medical Center, Ichilov Hospital, Israel.
Dermatology. 1994;189(1):1-4. doi: 10.1159/000246749.
Traditionally, drugs that are capable of inducing pemphigus are divided into two main groups according to their chemical structure, in particular, the existence of a sulfhydryl group in their molecule. Thus, two groups are formed: (1) drugs containing a sulfhydryl radical (thiol drugs or SH drugs) and (2) nonthiol or other drugs. Much emphasis has been put on the role of the sulfhydryl group in the pathogenesis of drug-induced pemphigus. The effects of this group have been extensively studied, and a logical paradigm on the mode of its action has been created. However, no attempt has been made to search for other biochemical radicals which might have an influence on the activation/triggering of this disease. The aim of the present report is to draw attention to a chemical group common to the molecule of several drugs that have been associated with the induction of pemphigus. Careful analysis of the chemical structure of nonthiol drugs known to induce pemphigus revealed that several of them share an active amide group in their molecule. We believe that this group might be responsible for the induction of the disease; thus, a third group of drugs capable of triggering pemphigus can be formed, namely drugs containing an active amide group. Several drugs of this group are discussed.
传统上，能够诱发天疱疮的药物根据其化学结构，特别是分子中巯基的存在，分为两大类。因此，形成了两组：（1）含有巯基的药物（硫醇类药物或SH药物）和（2）非硫醇类或其他药物。巯基在药物性天疱疮发病机制中的作用受到了高度重视。对该基团的作用进行了广泛研究，并建立了关于其作用方式的合理范式。然而，尚未尝试寻找可能对这种疾病的激活/触发有影响的其他生化基团。本报告的目的是提请注意几种与天疱疮诱发相关的药物分子中共同存在的一个化学基团。对已知能诱发天疱疮的非硫醇类药物的化学结构进行仔细分析后发现，其中几种药物的分子中都有一个活性酰胺基团。我们认为该基团可能是诱发该病的原因；因此，可以形成第三类能够引发天疱疮的药物，即含有活性酰胺基团的药物。本文讨论了该类中的几种药物。
