用于细菌趋化性受体跨膜信号传导的“冻结”动态二聚体模型。
"Frozen" dynamic dimer model for transmembrane signaling in bacterial chemotaxis receptors.
作者信息
Kim S H
机构信息
Department of Chemistry, University of California, Berkeley 94720.
出版信息
Protein Sci. 1994 Feb;3(2):159-65. doi: 10.1002/pro.5560030201.
Abstract
The crystal structures of the ligand binding domain of a bacterial aspartate receptor suggest a simple mechanism for transmembrane signaling by the dimer of the receptor. On ligand binding, one domain rotates with respect to the other, and this rotational motion is proposed to be transmitted through the membrane to the cytoplasmic domains of the receptor.
摘要
一种细菌天冬氨酸受体的配体结合结构域的晶体结构提示了该受体二聚体进行跨膜信号传导的一种简单机制。在配体结合时，一个结构域相对于另一个结构域发生旋转，并且这种旋转运动被认为会通过膜传递到受体的细胞质结构域。
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