酸性鞘磷脂酶拥有一个与其激活蛋白（鞘脂激活蛋白B和D）同源的结构域。
Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D.
作者信息
Ponting C P
机构信息
Department of Biochemistry, University of Oxford, United Kingdom.
出版信息
Protein Sci. 1994 Feb;3(2):359-61. doi: 10.1002/pro.5560030219.
Abstract
An N-terminal region of the acid sphingomyelinase sequence (residues 89-165) is shown to be homologous to saposin-type sequences. By analogy with the known functions of saposins, this sphingomyelinase saposin-type domain may possess lipid-binding and/or sphingomyelinase-activator properties. This finding may prove to be important in the understanding of Niemann-Pick disease, which results from sphingomyelinase deficiency.
摘要
酸性鞘磷脂酶序列的N端区域（第89 - 165位氨基酸残基）显示与鞘脂激活蛋白（saposin）类型的序列具有同源性。通过与鞘脂激活蛋白已知功能进行类比，该鞘磷脂酶的鞘脂激活蛋白类型结构域可能具有脂质结合和/或鞘磷脂酶激活特性。这一发现可能在理解由鞘磷脂酶缺乏引起的尼曼-匹克病方面具有重要意义。
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