Bigler E D, Burr R, Gale S, Norman M, Kurth S, Blatter D, Abildskov T
Department of Psychology, BYU, Provo, Utah 84602.
Brain Inj. 1994 Apr;8(3):231-8. doi: 10.3109/02699059409150975.
This study compared the ventricle-to-brain ratio (VBR) of the day-of-injury (DOI) computerized tomogram (CT) in traumatic brain-injured (TBI) patients with post-injury (2 months or greater) magnetic resonance (MR) VBRs in the same patients and in medical control subjects. The DOI VBR did not differ significantly from the medical controls, but both (DOI and medical control VBR) differed significantly from post-injury VBR. Additionally, a case study is presented wherein MR imaging studies were obtained prior to TBI so that a direct comparison of pre-injury to DOI to post-injury changes could be made. In this case the pre-injury and DOI VBRs were within approximately 9% of each other. In contrast, the post-injury VBR demonstrated over a 100% increase in comparison to either the pre-injury or DOI scan. This case and another case are illustrated using three-dimensional image analysis to represent ventricular change over time. These cases, along with the similarity of the DOI VBR with the medical controls, suggests that the DOI VBR can be utilized as an estimate or index of pre-injury ventricle/brain morphology. This will permit the use of DOI CT data for within-subject designs in TBI research that examines the course of degenerative changes over time.
本研究比较了创伤性脑损伤（TBI）患者受伤当日（DOI）计算机断层扫描（CT）的脑室与脑比率（VBR）与同一患者伤后（2个月或更长时间）磁共振（MR）VBR以及医学对照受试者的VBR。DOI时的VBR与医学对照无显著差异，但两者（DOI时的VBR和医学对照的VBR）与伤后的VBR均有显著差异。此外，还介绍了一个病例研究，其中在TBI之前进行了MR成像研究，以便能够直接比较伤前、DOI时和伤后的变化。在这个病例中，伤前和DOI时的VBR彼此相差约9%。相比之下，伤后的VBR与伤前或DOI扫描相比增加了100%以上。使用三维图像分析展示了该病例和另一个病例随时间的脑室变化。这些病例以及DOI时的VBR与医学对照的相似性表明，DOI时的VBR可作为伤前脑室/脑形态的估计值或指标。这将允许在TBI研究中使用DOI时的CT数据进行个体内设计，以研究随时间的退行性变化过程。
