Gale S D, Johnson S C, Bigler E D, Blatter D D
LDS Hospital, Salt Lake City, UT 84103, USA.
J Int Neuropsychol Soc. 1995 Jan;1(1):17-28. doi: 10.1017/s1355617700000060.
Morphometric analysis of magnetic resonance (MR) scans in 88 traumatic brain injury (TBI) patients demonstrated significantly larger ventricle-to-brain ratios (VBR) and temporal horn volumes, and significantly smaller fornix-to-brain ratios (FBR) and corpus callosum (CC) area measurements, compared to 73 controls. Additionally, TBI patients were grouped according to Glasgow Coma Scale (GCS) for a within-TBI sample comparison so that severity of injury on brain morphology could be examined. The severe TBI group (GCS = 3-6) differed from the mild and moderate injury groups on measures of the internal capsule, VBR, temporal horn volume, and CC. In a separate analysis wherein the TBI subjects were grouped by degree of fornix atrophy, the group with the smallest fornix size demonstrated the lowest memory performance. Furthermore, anatomic measures correlated with severity of injury, and tests of memory and motor function. Results demonstrate the diffuse nature of degeneration in TBI with more severe injury, and that quantified MR identified morphologic changes relate to neuropsychological outcome.
对88名创伤性脑损伤（TBI）患者的磁共振（MR）扫描进行形态计量分析，结果显示，与73名对照组相比，TBI患者的脑室与脑比率（VBR）和颞角体积显著更大，穹窿与脑比率（FBR）和胼胝体（CC）面积测量值显著更小。此外，根据格拉斯哥昏迷量表（GCS）对TBI患者进行分组，以便在TBI样本内部进行比较，从而能够检查脑形态学损伤的严重程度。重度TBI组（GCS = 3 - 6）在内囊、VBR,、颞角体积和CC测量指标上与轻度和中度损伤组存在差异。在另一项分析中，根据穹窿萎缩程度对TBI受试者进行分组，穹窿尺寸最小的组记忆表现最差。此外，解剖学测量指标与损伤严重程度、记忆和运动功能测试相关。结果表明，TBI中的变性具有弥漫性，损伤越严重，且定量MR识别出的形态学变化与神经心理学结果相关。
