从越南中部采集的越南人参（Panax vietnamensis Ha et Grushv.）中提取的皂苷。III.

Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. III.

作者信息

Duc N M, Kasai R, Ohtani K, Ito A, Nham N T, Yamasaki K, Tanaka O

机构信息

Science-Production Centre of Vietnamese Ginseng, Ho Chi Minh City University of Medicine and Pharmacy.

出版信息

Chem Pharm Bull (Tokyo). 1994 Mar;42(3):634-40. doi: 10.1248/cpb.42.634.

DOI:10.1248/cpb.42.634

PMID:8004713

Abstract

Five new dammarane saponins derived from four new aglycones were isolated from the rhizomes and roots of Panax vietnamensis Ha et Grushv. On the basis of physicochemical and spectral evidence, the structures of these compounds were established as 6-O-beta-D-glucopyranosyl 20(S),25-epoxydammarane-3 beta,6 alpha,12 beta,24 alpha-tetrol (1), 6-O-beta-D-xylopyranosyl-(1-->2)-beta-D-glucopyranosyl 20(S),25-epoxydammarane-3 beta,6 alpha,12 beta,24 alpha-tetrol (2), 6-O-beta-D-glucopyranosyl dammarane-3 beta,6 alpha,12 beta,20(S),24 xi,25-hexol (5), 3-O-[beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl]-20-O-beta-D- glucopyranosyl dammarane-3 beta,12 beta,20(S),24 xi,25-pentol (8) and 6-O-beta-D-xylopyranosyl-(1-->2)-beta-D-glucopyranosyl 20(S),24(S)-epoxydammarane-3 beta,6 alpha,12 beta,25 xi,26-pentol (10). The trivial names, vina-ginsenoside-R10, -R11, -R12, -R13 and -R14, respectively, were assigned to the new saponins.

摘要

从越南人参（Panax vietnamensis Ha et Grushv.）的根茎中分离出了五种由四种新苷元衍生而来的达玛烷型皂苷。基于理化性质和光谱证据，确定这些化合物的结构分别为6-O-β-D-吡喃葡萄糖基20(S),25-环氧达玛烷-3β,6α,12β,24α-四醇（1）、6-O-β-D-吡喃木糖基-(1→2)-β-D-吡喃葡萄糖基20(S),25-环氧达玛烷-3β,6α,12β,24α-四醇（2）、6-O-β-D-吡喃葡萄糖基达玛烷-3β,6α,12β,20(S),24ξ,25-己醇（5）、3-O-[β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基]-20-O-β-D-吡喃葡萄糖基达玛烷-3β,12β,20(S),24ξ,25-戊醇（8）和6-O-β-D-吡喃木糖基-(1→2)-β-D-吡喃葡萄糖基20(S),24(S)-环氧达玛烷-3β,6α,12β,25ξ,26-戊醇（10）。这几种新皂苷分别被赋予俗名越南人参皂苷-R10、-R11、-R12、-R13和-R14。