Nguyen M D, Kasai R, Ohtani K, Ito A, Nguyen T N, Yamasaki K, Tanaka O
Science-Production Centre of Vietnamese Ginseng, Ho Chi Minh City University of Medicine and Pharmacy, Vietnam.
Chem Pharm Bull (Tokyo). 1994 Jan;42(1):115-22. doi: 10.1248/cpb.42.115.
Further investigation on the saponin composition of rhizomes and roots of Panax vietnamensis HA et GRUSHV. has resulted in the isolation and structural elucidation of seven new dammarane saponins named vina-ginsenosides-R3 (12), -R4 (11), -R5 (16), -R6 (17), -R7 (6), -R8 (20), -R9 (22), together with the identification of six known saponins including 20-gluco-ginsenoside-Rf (10), ginsenoside-Rc (4), notoginsenoside-R6 (9), quinquenoside-R1 (5), gypenoside XVII (2) and majoroside F1 (21). The structures of the novel saponins were established on the basis of chemical and spectral evidence. Vina-ginsenoside-R3 is the first naturally occurring glycoside of dammarenediol II, while vina-ginsenosides-R5 and -R6, two ocotillol-type saponins, are two other examples of saponins having the rare alpha-glucosyl linkage.
对越南人参（Panax vietnamensis HA et GRUSHV.）根茎和根的皂苷成分进行的进一步研究，已分离并阐明了七种新的达玛烷型皂苷的结构，它们分别被命名为越南人参皂苷-R3（12）、-R4（11）、-R5（16）、-R6（17）、-R7（6）、-R8（20）、-R9（22），同时还鉴定出六种已知皂苷，包括20-葡萄糖基人参皂苷-Rf（10）、人参皂苷-Rc（4）、三七皂苷-R6（9）、五叶参皂苷-R1（5）、绞股蓝皂苷XVII（2）和大叶三七苷F1（21）。这些新型皂苷的结构是基于化学和光谱证据确定的。越南人参皂苷-R3是达玛烷二醇II的首个天然糖苷，而越南人参皂苷-R5和-R6这两种奥寇梯罗醇型皂苷，则是具有罕见α-葡萄糖基连接的皂苷的另外两个例子。
