[从猪身上分离出的微生物对庆大霉素水溶液和蛋白质溶液的敏感性]

[Sensitivity of microorganisms isolated from swine to aqueous and proteinic solutions of gentamycin].

作者信息

Boiadzhieva A

出版信息

Vet Med Nauki. 1978;15(1):78-83.

Abstract

Employing a microbiologic method (in vitro) the activity was investigated of Gentamicin DSO Pharmachim, dissolved in water, in normal swine gamma-globulin, and in normal swine polyglobulin with regard to swine strains of Escherichia coli, Salmonella choleraesis Bordetella bronchiseptica, and Pseudomonas aeruginosa as well as Mycoplasms. A strong sensitivity was found to exsist in all tested strains (except for the Mycoplasms) to gentamycin both in a water and in a protein solution. The in vivo testing of the therapeutic effect of the two types of solutions in an experimental infection in albino mice revealed that the differences found in the activity of the various gentamicin solutions were statistically insignificant. The step agglutination test was used to follow up the effect of gentamycin on the OK agglutinating antibodies of a gamma-globulin preparation against oedema disease in pigs. Results showed a slight increase in the agglutinating activity of the gamma-globulin antibodies under the effect of the antibiotic.

摘要

采用微生物学方法（体外），研究了溶于水、正常猪γ球蛋白和正常猪多球蛋白中的法玛新硫酸庆大霉素对猪源大肠杆菌、霍乱沙门氏菌、支气管败血波氏杆菌、铜绿假单胞菌以及支原体菌株的活性。结果发现，除支原体外，所有受试菌株在水和蛋白质溶液中对庆大霉素均表现出很强的敏感性。对白化小鼠进行实验性感染，测试这两种溶液的治疗效果，结果显示，不同庆大霉素溶液活性的差异在统计学上不显著。采用试管凝集试验追踪庆大霉素对γ球蛋白制剂针对猪水肿病的OK凝集抗体的影响。结果表明，在抗生素作用下，γ球蛋白抗体的凝集活性略有增加。