Traber M G
Department of Medicine, New York University School of Medicine, NY 10016.
Free Radic Biol Med. 1994 Feb;16(2):229-39. doi: 10.1016/0891-5849(94)90148-1.
Vitamin E, a lipid soluble antioxidant, is transported in plasma lipoproteins. This review will summarize the mechanisms for the preferential incorporation of RRR-alpha-tocopherol into lipoproteins. Special attention is devoted to the hepatic tocopherol binding protein, and to patients who are vitamin E deficient because they apparently have a genetic defect in this protein. The regulation of plasma vitamin E by the tocopherol binding protein as a determinant of the biologic activity of various forms of vitamin E is also discussed.
维生素E是一种脂溶性抗氧化剂，通过血浆脂蛋白进行运输。本综述将总结RRR-α-生育酚优先掺入脂蛋白的机制。特别关注肝脏生育酚结合蛋白，以及因该蛋白存在明显遗传缺陷而维生素E缺乏的患者。还讨论了生育酚结合蛋白对血浆维生素E的调节作用，它是各种形式维生素E生物活性的决定因素。
