NYU School of Medicine, New York, NY, USA.
Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Eur J Nutr. 2019 Mar;58(2):609-617. doi: 10.1007/s00394-018-1646-9. Epub 2018 Feb 26.
To assess the cross-sectional and longitudinal association between self-reported vitamin C + E dietary supplementation and markers of grip strength and frailty in community-dwelling Swiss adults.
Population-based study including 3277 participants (1722 women) aged 40-80 years at baseline. The associations between vitamin C + E dietary supplementation and grip strength were examined cross-sectionally and after a follow-up of 5.2 years on average.
There were 253 (7.7%) self-reported vitamin C + E supplement users. Female users had significantly lower grip strength than non-users (average ± standard deviation: 24.3 ± 6.1 versus 25.6 ± 6.1 kg, respectively). However, the association disappeared after multivariate adjustment (24.7 ± 0.5 versus 25.6 ± 0.1 kg, for users versus non-users, respectively). No differences were found in men regarding grip strength. No differences were found in the highest quintile of grip strength or prevalence of low grip strengthin in users versus non-users during cross-sectional analysis for both genders. After 5.2 years of follow-up, no associations were found between vitamin C + E supplementation and change in grip strength for raw values (difference between baseline and follow-up: 1.2 ± 5.0 versus 0.4 ± 5.2 kg for female and 0.6 ± 6.5 versus 1.1 ± 6.8 kg for male users and non-users, respectively) or after multivariable adjustment (1.2 ± 0.5 versus 0.4 ± 0.1 kg for female and 0.6 ± 0.8 versus 1.1 ± 0.2 kg for male users and non-users, respectively) when taking baseline vitamin C + E supplementation into account. No association was also found for incidence of low grip strength.
In a sample of community-dwelling Swiss adults, vitamin C + E supplementation neither improved grip strength nor prevented low-grip strength over a 5-year period.
评估自我报告的维生素 C+E 饮食补充与握力和虚弱标志物在瑞士社区居住的成年人中的横断面和纵向关联。
本研究为基于人群的研究，共纳入了 3277 名参与者（女性 1722 名），年龄在基线时为 40-80 岁。分别在横断面和平均随访 5.2 年后，研究了维生素 C+E 饮食补充与握力之间的关联。
有 253 名（7.7%）自我报告的维生素 C+E 补充剂使用者。女性使用者的握力明显低于非使用者（平均±标准差：24.3±6.1 与 25.6±6.1 kg，分别）。然而，经过多变量调整后，这种关联消失了（分别为 24.7±0.5 与 25.6±0.1 kg）。男性在握力方面没有差异。在横断面分析中，无论男女，在握力最强的五分位数或握力弱的发生率方面，使用者与非使用者之间均无差异。在 5.2 年的随访后，维生素 C+E 补充与握力变化之间没有关联（女性和男性使用者和非使用者的基线与随访之间的差值分别为 1.2±5.0 与 0.4±5.2 kg 和 0.6±6.5 与 1.1±6.8 kg）或经过多变量调整后（女性和男性使用者和非使用者的差值分别为 1.2±0.5 与 0.4±0.1 kg 和 0.6±0.8 与 1.1±0.2 kg），同时考虑了基线时的维生素 C+E 补充。握力弱的发生率也没有关联。
在瑞士社区居住的成年人样本中，维生素 C+E 补充剂既没有改善握力，也没有在 5 年内预防握力减弱。
