Tournaye H, Janssens R, Devroey P, van Steirteghem A
Centre for Reproductive Medicine, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel), Belgium.
Int J Androl. 1994 Feb;17(1):1-8. doi: 10.1111/j.1365-2605.1994.tb01200.x.
In order to evaluate the effects of pentoxifylline on sperm motility and longevity, a controlled in-vitro study was conducted on normozoospermic donor semen samples using the Cellsoft automated system for sperm motility analysis. After incubation and selection, pentoxifylline was found to improve the recovery of spermatozoa and to increase their velocity. In the subgroup of progressively motile spermatozoa, curvilinear velocity was also enhanced. It is concluded that pentoxifylline has an effect on the vigour, but not on the pattern, of sperm motion. Pentoxifylline did not improve the motility characteristics of senescent spermatozoa in normozoospermic sperm samples. Sperm survival, as shown by supra-vital staining, and motility longevity both decreased with time after pentoxifylline treatment.
为了评估己酮可可碱对精子活力和存活时间的影响，使用Cellsoft自动系统对正常精子捐献者的精液样本进行了体外对照研究，以分析精子活力。经过孵育和筛选后，发现己酮可可碱可提高精子的回收率并增加其速度。在进行性运动精子亚组中，曲线速度也有所提高。得出的结论是，己酮可可碱对精子运动的活力有影响，但对运动模式没有影响。己酮可可碱并未改善正常精子样本中衰老精子的活力特征。经超活染色显示，己酮可可碱处理后，精子存活率和活力存活时间均随时间下降。
