Benignus V A
Human Studies Division, US Environmental Protection Agency, Research Triangle Park 27711.
J Appl Physiol (1985). 1994 Mar;76(3):1310-6. doi: 10.1152/jappl.1994.76.3.1310.
In the absence of reliable data, this work was performed to estimate the dose-effects function of carboxyhemoglobin (HbCO) on behavior in humans. Meta analysis is the quantitative analysis of the combined findings of a number of research reports. By meta analysis, an HbCO-behavior dose-effects function was estimated for rats and corrected for effects of hypothermia (which accompanies acute HbCO increases in rats but not in humans). By use of pulmonary function models and blood gas equations, equivalent HbCO values were calculated for data in the literature on hypoxic hypoxia and behavior. Another meta analysis was performed to fit a dose-effects function to the equivalent HbCO data and to correct for the behavioral effects of hypocapnia (which usually occurs during hypoxic hypoxia but not with HbCO elevation). The two extrapolations agreed closely and indicated that, for healthy sedentary persons, 18-25% HbCO would be required to produce a 10% decrement in behavior. Confidence intervals are computed to characterize the uncertainty. Frequent reports of lower-level effects are discussed.
在缺乏可靠数据的情况下，开展本研究以评估碳氧血红蛋白（HbCO）对人类行为的剂量效应函数。荟萃分析是对多篇研究报告的综合结果进行定量分析。通过荟萃分析，估算了大鼠的HbCO-行为剂量效应函数，并对体温过低的影响进行了校正（体温过低在大鼠急性HbCO升高时会出现，但在人类中不会出现）。利用肺功能模型和血气方程，针对文献中关于低氧性缺氧和行为的数据计算了等效HbCO值。进行了另一项荟萃分析，以拟合等效HbCO数据的剂量效应函数，并校正低碳酸血症的行为效应（低碳酸血症通常在低氧性缺氧期间出现，但不会随着HbCO升高而出现）。两次外推结果高度一致，表明对于健康的久坐不动者，行为下降10%需要18%-25%的HbCO。计算了置信区间以描述不确定性。讨论了关于较低水平效应的频繁报告。
