Cowan L D, Hudson L, Bobele G, Chancellor I, Baker J
Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
J Child Neurol. 1994 Apr;9(2):173-7. doi: 10.1177/088307389400900214.
A pilot case-control study was done to collect data on whether susceptibility to newborn encephalopathy and neonatal seizures is influenced by the degree of maternal-fetal sharing of HLA antigens. Cases included 13 infants with moderate or severe newborn encephalopathy and seven infants with neonatal seizures but no other signs of encephalopathy. Controls were neurologically normal infants matched to cases by date of birth, sex, race, and payment status. Infants and their mothers were typed for HLA-A, -B, -DR, and -DQ antigens. The observed frequency of sharing of maternal antigens was greater than expected (ie, 0.5) for cases compared to controls at the HLA-B, -DR, and -DQ loci but not for HLA-A. The risk of neurologic problems in the neonatal period was increased 6.3 times when there was more than one match at the HLA-DR or -DQ locus. Placental abnormalities were noted at delivery only among cases, and the mean placental weight in cases was 598 g versus 695 g in controls. Further studies with sample sizes sufficiently large to statistically test this hypothesis are needed.
开展了一项病例对照试点研究，以收集关于新生儿脑病和新生儿惊厥易感性是否受母胎 HLA 抗原共享程度影响的数据。病例包括 13 例中度或重度新生儿脑病患儿以及 7 例有新生儿惊厥但无其他脑病体征的患儿。对照为按出生日期、性别、种族和付费状态与病例匹配的神经功能正常的婴儿。对婴儿及其母亲进行 HLA - A、- B、- DR 和 - DQ 抗原分型。在 HLA - B、- DR 和 - DQ 位点，病例组与对照组相比，母源抗原共享的观察频率高于预期（即 0.5），但 HLA - A 位点并非如此。当 HLA - DR 或 - DQ 位点有多个匹配时，新生儿期出现神经问题的风险增加了 6.3 倍。仅在病例组中观察到分娩时胎盘异常，病例组胎盘平均重量为 598 g，而对照组为 695 g。需要开展样本量足够大的进一步研究以对该假设进行统计学检验。
