Cauchi M N, Tait B, Wilshire M I, Koh S H, Mraz G, Kloss M, Pepperell R
Department of Pathology, Royal Women's Hospital, Melbourne, Australia.
Am J Reprod Immunol Microbiol. 1988 Sep;18(1):28-31. doi: 10.1111/j.1600-0897.1988.tb00229.x.
Eighty-five couples with habitual abortion were studied: 43 were primary aborters (i.e., had no advanced pregnancy beyond 20 weeks gestation), and 42 were secondary aborters. The only significant finding in primary female aborters was a reduction in the incidence of B35. In contrast, in secondary female aborters there was a reduction in the incidence of DR3 and A1/B8/DR3 and an increase in the degree of homozygosity of HLA B. In the male partners of primary aborters, there was a reduced incidence of DR3 and A1/B8/DR3. In addition, in male partners of both primary and secondary aborters, there was increased HLA-B homozygosity and increased frequency of DR4-5 phenotype. Increased sharing of HLA antigens between partners was not found to be significantly different from the control population. These findings emphasize that primary and secondary female aborters form distinct populations, which could explain differences in immunological responses to various antigens, including fetal-related antigens. The closely related findings in female secondary aborters and male partners of primary aborters are intriguing but cannot be explained. Whether or not these genetic markers bear any relationship to reproductive success remains to be determined.
对85对习惯性流产夫妇进行了研究：43对为原发性流产者（即妊娠未超过20周），42对为继发性流产者。原发性女性流产者唯一显著的发现是B35发生率降低。相比之下，继发性女性流产者中DR3和A1/B8/DR3的发生率降低，HLA B的纯合度增加。在原发性流产者的男性伴侣中，DR3和A1/B8/DR3的发生率降低。此外，在原发性和继发性流产者的男性伴侣中，HLA-B纯合度增加，DR4-5表型频率增加。未发现伴侣之间HLA抗原共享增加与对照组有显著差异。这些发现强调原发性和继发性女性流产者构成不同群体，这可以解释对包括胎儿相关抗原在内的各种抗原的免疫反应差异。继发性女性流产者和原发性流产者男性伴侣中密切相关的发现很有趣，但无法解释。这些基因标记是否与生殖成功有任何关系还有待确定。
