Warady B D, Lindsley C B, Robinson F G, Lukert B P
Childrens Rehabilitation Unit, University of Kansas Medical Center, Kansas City 66160-7330.
J Rheumatol. 1994 Mar;21(3):530-5.
Because children with rheumatic disease receiving longterm corticosteroids are at high risk for developing osteoporosis, we attempted to determine whether nutritional supplementation would improve bone status in this group of children.
In a crossover design study, 10 corticosteroid treated children with rheumatic disease and osteoporosis received calcium and vitamin D supplementation for 6 months to determine their effect on bone density. They were then studied for 6 months without added nutrition supplements. The mean age was 13.1 years with a mean duration of disease of 4.2 years. Six patients had juvenile rheumatoid arthritis, 2 had systemic lupus erythematosus and 2 had mixed connective tissue disease. These children obtained a minimum of 1 g of calcium and 400 IU of vitamin D daily from diet and added supplements. Dual photon absorptiometry, laboratory and dietary data were obtained at baseline, 6 months, and one year.
Spinal bone density significantly improved with supplementation. Osteocalcin values remained low throughout the study.
Our results suggest some children with rheumatic disease receiving corticosteroids would benefit from calcium and vitamin D supplementation.
由于接受长期皮质类固醇治疗的风湿性疾病患儿发生骨质疏松的风险很高，我们试图确定营养补充是否能改善该组儿童的骨骼状况。
在一项交叉设计研究中，10名接受皮质类固醇治疗且患有风湿性疾病和骨质疏松症的儿童接受了6个月的钙和维生素D补充，以确定其对骨密度的影响。然后对他们进行了6个月的研究，期间不添加营养补充剂。平均年龄为13.1岁，平均病程为4.2年。6例患有幼年类风湿性关节炎，2例患有系统性红斑狼疮，2例患有混合性结缔组织病。这些儿童每天从饮食和添加的补充剂中获取至少1克钙和400国际单位的维生素D。在基线、6个月和1年时获取双能光子吸收法、实验室和饮食数据。
补充后脊柱骨密度显著改善。在整个研究过程中骨钙素值一直较低。
我们的结果表明，一些接受皮质类固醇治疗的风湿性疾病患儿将从钙和维生素D补充中受益。
