Kawakatsu S, Komatani A
Department of Neuropsychiatry, Yamagata University School of Medicine.
Nihon Rinsho. 1994 May;52(5):1180-4.
We measured regional cerebral blood flow (rCBF) in depressed patients using Xe-133 inhalation single photon emission computerized tomography (SPECT; HEADTOME). Thirty-two medicated mildly depressed patients, six bipolar (BP) and 26 unipolar (UP), and 20 control subjects participated in the study. Compared to the controls, UP patients showed a significant decrease of rCBF in the bilateral frontal and the parietal regions, which were dominant in the left hemisphere, while BP patients showed no decrease of rCBF and mean CBF. Comparison of rCBF between before and after treatment with antidepressants in 8 depressed patients revealed an increased rCBF after the improvement in the left superior frontal, the left parietal and the right temporal regions which are critical areas for the development of depression.
我们使用氙 - 133吸入单光子发射计算机断层扫描（SPECT；HEADTOME）测量了抑郁症患者的局部脑血流量（rCBF）。32名接受药物治疗的轻度抑郁症患者参与了研究，其中6名双相情感障碍（BP）患者和26名单相抑郁症（UP）患者，另有20名对照受试者。与对照组相比，单相抑郁症患者在双侧额叶和顶叶区域的rCBF显著降低，这些区域在左半球占主导地位，而双相情感障碍患者的rCBF和平均脑血流量没有降低。对8名抑郁症患者进行抗抑郁药治疗前后的rCBF比较发现，在左额上回、左顶叶和右颞叶区域病情改善后rCBF增加，这些区域是抑郁症发病的关键区域。
