Devous M D, Stokely E M, Chehabi H H, Bonte F J
J Cereb Blood Flow Metab. 1986 Feb;6(1):95-104. doi: 10.1038/jcbfm.1986.12.
Regional CBF (rCBF) was measured quantitatively using the inert-gas washout technique with xenon-133 and single-photon emission computed tomography. Tomographic data were reconstructed by filtered back projection, and flow was calculated according to the double-integral method. Ninety-seven subjects ranging in age from 20 to 59 years received a single examination; eight of these received a second examination within 1 h of the first; seven others received a second examination separated from the first by 1-10 days. Transverse-section images were obtained at 2, 6, and 10 cm above and parallel to the canthomeatal line (CML). Cortical gray matter flows were obtained from 12 brain regions in the slice 6 cm above the CML, and cerebellar and inferior cerebral gray matter flows were obtained from 4 regions in the slice 2 cm above the CML. Mean gray matter flow was 72 +/- 12 ml/min/100 g, with highest flows in the parietal lobes and visual cortex. No significant differences in rCBF occurred when a second study followed the first by 30 min to 10 days. Right-sided rCBF was slightly higher than left in all regions except frontal and parietal lobes where there was no difference. Flow was higher in women than in men and declined mildly with age for both sexes (slope = -0.33 ml/min/100 g/year; p less than 0.05).
采用氙-133惰性气体洗脱技术和单光子发射计算机断层扫描定量测量局部脑血流量（rCBF）。断层扫描数据通过滤波反投影重建，并根据双积分法计算血流量。97名年龄在20至59岁之间的受试者接受了单次检查；其中8人在首次检查后1小时内接受了第二次检查；另外7人在首次检查后1至10天接受了第二次检查。在与眦耳线（CML）平行且在其上方2厘米、6厘米和10厘米处获取横断面图像。在CML上方6厘米切片的12个脑区获取皮质灰质血流量，在CML上方2厘米切片的4个区域获取小脑和大脑下部灰质血流量。平均灰质血流量为72±12毫升/分钟/100克，顶叶和视觉皮层血流量最高。当第二次研究在第一次研究后30分钟至10天进行时，rCBF无显著差异。除额叶和顶叶无差异外，所有区域右侧rCBF略高于左侧。女性的血流量高于男性，且两性血流量均随年龄略有下降（斜率=-0.33毫升/分钟/100克/年；p<0.05）。
