Yamada T
Kashiwa City Hospital.
Nihon Rinsho. 1994 May;52(5):1311-7.
In an attempt to study "manic-depressive" affairs associated with endocrine and mental disorders, our clinical data are analyzed before and after appropriate treatment in Cushing's disease, Cushing's syndrome, hyperthyroid Graves' disease and primary hypothyroidism. Although our data do not provide definite findings on manic-depressive affairs associated with Cushing's disease and syndrome, review data by others indicated a high incidence of depression under untreated condition and its disappearance after appropriate treatment. In contrast, patients with adrenocortical insufficiency did have a depression but this was cleared after supplemental therapy. In hyperthyroid Graves' disease, a number of emotional and mental instability and irritability were noticed before the treatment, but these abnormalities all disappeared after appropriate treatment for 3-6 months. In contrast, patients with primary hypothyroidism did show lethargy and apathy, and these abnormalities disappeared after appropriate treatment. From the data accumulated, it is concluded that adrenal steroid and thyroid hormone do affect the functions of nervous system and, as a result, cause a number of clinical symptoms. The exact biochemical processes underlying these abnormalities are not known and remains for further investigations.
为了研究与内分泌和精神障碍相关的“躁狂抑郁”事件，我们分析了库欣病、库欣综合征、甲状腺功能亢进的格雷夫斯病和原发性甲状腺功能减退症患者在适当治疗前后的临床数据。尽管我们的数据并未提供与库欣病和综合征相关的躁狂抑郁事件的确切结果，但其他人的综述数据表明，在未经治疗的情况下抑郁症发病率很高，而在适当治疗后抑郁症消失。相比之下，肾上腺皮质功能不全的患者确实患有抑郁症，但补充治疗后抑郁症得以消除。在甲状腺功能亢进的格雷夫斯病中，治疗前发现了一些情绪和精神不稳定以及易怒的情况，但经过3至6个月的适当治疗后，这些异常情况均消失。相比之下，原发性甲状腺功能减退症患者确实表现出嗜睡和冷漠，而经过适当治疗后这些异常情况消失。根据积累的数据得出结论，肾上腺类固醇和甲状腺激素确实会影响神经系统的功能，从而导致一些临床症状。这些异常情况背后的确切生化过程尚不清楚，有待进一步研究。
