Nagatoshi H, Itoh I, Takeda S
Kurosaki Factory, Mitsubishi Kasei Corp.
Sangyo Igaku. 1994 Mar;36(2):106-13. doi: 10.1539/joh1959.36.2_106.
With the revision made to the Regulation on the Prevention of Organic Solvent Poisoning in June 30, 1989, analysis of urine must be made for metabolites as a part of the health examination of workers exposed to xylene, N,N-dimethylformamide, styrene, 1,1,1-trichloroethane, tetrachloroethylene, trichloroethylene, toluene, and n-hexane. In accordance with this Regulation, health examinations were conducted at eight factories of five chemical manufactures in 1990. This report presents the results obtained for 1,073 workers as compiled by the Committee of Industrial Health of the Japan Urea and Ammonium Sulfate Industry Association. 1) The results of data analysis have shown that workers whose urine was collected when they had been exposed to an imperceptible degree to organic solvent or who underwent urine collection during an unknown period of time after exposure numbered 615 or 57.3% of all the workers. 2) Workers whose urine was collected within about 5 hours after exposure numbered 458 (42.7%). The metabolite concentrations in these workers were significantly lower than the BEI values. 3) It may be concluded from the results that workers were exposed to organic solvents to an extremely small extent during organic solvent handling operations at chemical industry factories which maintain good control over toxic materials.
随着1989年6月30日《有机溶剂中毒预防条例》的修订，作为对接触二甲苯、N，N - 二甲基甲酰胺、苯乙烯、1,1,1 - 三氯乙烷、四氯乙烯、三氯乙烯、甲苯和正己烷的工人进行健康检查的一部分，必须对尿液中的代谢物进行分析。根据该条例，1990年在五家化学制品制造商的八家工厂进行了健康检查。本报告介绍了日本尿素和硫酸铵工业协会工业卫生委员会汇总的1073名工人的检查结果。1）数据分析结果表明，在接触有机溶剂程度不明显时采集尿液的工人，或在接触后未知时间段内采集尿液的工人有615名，占所有工人的57.3%。2）在接触后约5小时内采集尿液的工人有458名（42.7%）。这些工人的代谢物浓度明显低于生物接触指数（BEI）值。3）从结果可以得出结论，在对有毒物质保持良好控制的化工工厂进行有机溶剂处理操作期间，工人接触有机溶剂的程度极小。
