Borg-Neczak K, Tjälve H
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala Biomedical Centre.
Pharmacol Toxicol. 1994 Mar;74(3):185-92. doi: 10.1111/j.1600-0773.1994.tb01097.x.
Oral administration of Ni2+ together with 8-hydroxyquinoline (8-OH-quinoline), 8-mercaptoquinoline (8-SH-quinoline) or 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol) resulted in increased tissue levels of the metal in several tissues of mice in comparison with animals given the Ni2+ alone. Ni2+ forms lipophilic complexes with these compounds and it can be assumed that this will facilitate the uptake of the Ni2+ over the walls of the gastrointestinal tract. Our results showed that 8-SH-quinoline, in contrast to 8-OH-quinoline and and clioquinol, induces a markedly changed distribution pattern of the Ni2+ in the body, with uptake of the metal in tissues such as the central nervous system, pigmented tissues, the pancreatic islets and the thyroid. It is probable that the Ni(2+)-complex with 8-SH-quinoline is stable enough to persist for a time period in the tissues and that the obtained pattern partly reflects the distribution of the complexed metal. In contrast, following the absorption from the gastrointestinal tract there may be a dissociation of the complexes between Ni2+ and 8-OH-quinoline or clioquinol, resulting in increased metal levels in various tissues, but with similar distribution as when the Ni2+ is given alone.
与单独给予Ni2+的动物相比，将Ni2+与8-羟基喹啉（8-OH-喹啉）、8-巯基喹啉（8-SH-喹啉）或5-氯-7-碘-8-羟基喹啉（氯碘羟喹）一起口服，会使小鼠多个组织中的金属组织水平升高。Ni2+与这些化合物形成亲脂性复合物，可以推测这将促进Ni2+在胃肠道壁上的吸收。我们的结果表明，与8-OH-喹啉和氯碘羟喹不同，8-SH-喹啉会导致体内Ni2+的分布模式发生明显变化，金属会在中枢神经系统、色素组织、胰岛和甲状腺等组织中摄取。很可能Ni(2+)与8-SH-喹啉形成的复合物足够稳定，能够在组织中持续一段时间，并且所得到的模式部分反映了络合金属的分布。相比之下，从胃肠道吸收后，Ni2+与8-OH-喹啉或氯碘羟喹之间的复合物可能会解离，导致各种组织中的金属水平升高，但分布与单独给予Ni2+时相似。
