Pothoff G, Wassermann K, Ostmann H
Medical Clinic III, University of Cologne, FRG.
Respiration. 1994;61(2):80-5. doi: 10.1159/000196311.
It is known that pulmonary function is impaired during the course of HIV infection even in early stages. In order to estimate the resulting reduction of exercise capacity, different groups of HIV patients were investigated. Group 1 consisted of 20 patients without a history of respiratory disease and without actual lung disease, group 2 of 18 patients with a former episode of Pneumocystis carinii pneumonia (PCP) without actual lung disease, and group III of 37 patients with different broncho-pulmonary complications including PCP. 20 normal subjects served as controls. Spirometry, diffusing capacity (DLCO) and exercise tests including arterial blood gas analysis (BGA) were performed in patients and controls. Compared to the controls group 1 patients revealed a decreased DLCO (TCO: 83 +/- 15 vs. 67 +/- 15% pred.norm.) while spirometric data were normal. VO2 and O2 pulse at the anaerobic threshold (17.7 +/- 5.1 vs. 14.3 +/- 2.6 ml/kg.min and 10.8 +/- 4.0 vs. 8.6 +/- 1.9 ml/beat, respectively) and maximum exercise (33.9 +/- 9.7 vs. 22.1 +/- 3.4 ml/kg.min and 15.0 +/- 5.0 vs. 11.3 +/- 2.5, respectively) were decreased, whereas AaDO2, VD/VT, and the HR/VO2 slope were normal. The reserves of heart rate and ventilation were high. Except for a reduced maximum work rate in group 1, no significant difference was found between groups 1 and 2. Group 3 patients differed most from groups 1 and 2 with respect to spirometry, DLCO and AaDO2, rather than VO2.(ABSTRACT TRUNCATED AT 250 WORDS)
众所周知，即使在HIV感染的早期阶段，其病程中肺功能也会受损。为了评估由此导致的运动能力下降情况，对不同组别的HIV患者进行了调查。第1组由20名无呼吸系统疾病史且无实际肺部疾病的患者组成，第2组由18名曾患卡氏肺孢子虫肺炎（PCP）但无实际肺部疾病的患者组成，第3组由37名患有包括PCP在内的不同支气管肺部并发症的患者组成。20名正常受试者作为对照。对患者和对照者进行了肺量计检查、弥散功能（DLCO）以及包括动脉血气分析（BGA）在内的运动测试。与对照组相比，第1组患者的DLCO降低（TCO：预计正常值的83±15%对67±15%），而肺量计数据正常。无氧阈值时的VO2和O2脉搏（分别为17.7±5.1对14.3±2.6 ml/kg·min和10.8±4.0对8.6±1.9 ml/次搏动）以及最大运动时的VO2和O2脉搏（分别为33.9±9.7对22.1±3.4 ml/kg·min和15.0±5.0对11.3±2.5）均降低，而AaDO2、VD/VT和HR/VO2斜率正常。心率和通气储备较高。除第1组的最大工作率降低外，第1组和第2组之间未发现显著差异。第3组患者在肺量计、DLCO和AaDO2方面与第1组和第2组差异最大，而非VO2。（摘要截取自250字）
