艾滋病毒/艾滋病感染者的健康相关生活质量和身体功能：病例对照设计。
Health-related quality of life and physical functioning in people living with HIV/AIDS: a case-control design.
机构信息
Department of Medical Rehabilitation, College of Health Sciences, Obafemi Awolowo University, and Department of Physiotherapy, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
出版信息
Health Qual Life Outcomes. 2013 Jun 26;11:106. doi: 10.1186/1477-7525-11-106.
BACKGROUND
Health-Related Quality of Life (HRQoL) and functional exercise capacity are important area of therapeutic interventions needed to improve the general health of People Living with HIV/AIDS (PLWH). However, the relationship between self-report and Performance-based Measure of Functional Capacity (PMFC) of PLWH is still obscure. This study compared the HRQoL and PMFC between a homogenous sample of clinical stage I PLWH and apparently healthy controls.
METHODS
This case-control study involved 74 consenting participants (37 PLWH and 37 controls) who completed the self-report SF-12 questionnaire and PMFC assessment using Six Minute Walk Test (6MWT). PMFC was expressed in terms of Six-Minute Walk Distance (6MWD), Six-Minute Walk Work (6MWW) and Maximum oxygen uptake (VO2max). Data were analyzed using descriptive statistics of mean and inferential statistics of independent t-test, ANOVA and Pearson's product moment correlation. Alpha level was set at 0.05.
RESULTS
There was no significant difference in the SF-12 Physical-health Component Score (PCS) of PLWH and the controls (p=0.782). However, the SF-12 Mental-health Component Score (MCS) of PLWH was higher than that of controls (p=0.040). 6MWD, 6MWW and VO2max were significantly lower for PLWH (p<0.05). Among PLWH, there was no significant gender differences in the PMFC (p>0.05) while PCS was higher among females. There was no significant correlation between PMFC variables and each of PCS and MCS for PLWH and controls (p>0.05) respectively.
CONCLUSION
Self-report physical health of clinical stage 1 PLWH and controls was comparable, while self-report mental health capacity was higher in PLWH than the controls. PMFC of PLWH was significantly lower compared to healthy controls without gender bias. Overall, self-report and performance-based measure of physical functional capacity of PLWH was not inter-related. Therefore understanding the factors that may influence exercise capacity of PLWH may help to develop effective exercise programmes for PLWH.
背景
健康相关生活质量（HRQoL）和功能运动能力是改善艾滋病毒/艾滋病感染者（PLWH）整体健康所必需的治疗干预的重要领域。然而，PLWH 的自我报告和基于表现的功能能力测量（PMFC）之间的关系仍然不清楚。本研究比较了临床 I 期 PLWH 同型样本与明显健康对照者之间的 HRQoL 和 PMFC。
方法
本病例对照研究纳入了 74 名同意参加的参与者（37 名 PLWH 和 37 名对照者），他们完成了自我报告的 SF-12 问卷和使用六分钟步行测试（6MWT）的 PMFC 评估。PMFC 以六分钟步行距离（6MWD）、六分钟步行工作量（6MWW）和最大摄氧量（VO2max）表示。使用均值描述性统计和独立 t 检验、方差分析和 Pearson 乘积矩相关的推断统计进行数据分析。α 水平设为 0.05。
结果
PLWH 和对照组的 SF-12 生理健康成分评分（PCS）无显著差异（p=0.782）。然而，PLWH 的 SF-12 心理健康成分评分（MCS）高于对照组（p=0.040）。PLWH 的 6MWD、6MWW 和 VO2max 显著较低（p<0.05）。在 PLWH 中，PMFC 无显著性别差异（p>0.05），而女性的 PCS 较高。PLWH 和对照组的 PMFC 变量与 PCS 和 MCS 之间均无显著相关性（p>0.05）。
结论
临床 I 期 PLWH 和对照组的自我报告身体健康状况相当，而 PLWH 的自我报告心理健康能力高于对照组。与健康对照组相比，PLWH 的 PMFC 显著较低，且无性别偏见。总体而言，PLWH 的自我报告和基于表现的身体功能能力测量之间没有相互关系。因此，了解可能影响 PLWH 运动能力的因素可能有助于为 PLWH 制定有效的运动计划。
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