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[在小鼠狼疮中，抗核小体抗体的出现先于抗双链DNA抗体和抗组蛋白抗体]

[The appearance of antinucleosome antibodies precedes that of anti-double-stranded DNA and anti-histones in murine lupus].

作者信息

Amoura Z, Chabre H, Bach J F, Jacob L

机构信息

Inserm U25, hôpital Necker, Paris.

出版信息

Rev Med Interne. 1993;14(10):980. doi: 10.1016/s0248-8663(05)80098-0.

DOI:10.1016/s0248-8663(05)80098-0
PMID:8009073
Abstract

Collected samples serum of 30 MRL lpr/lpr and 15 MRL MP +/+ were tested by ELISA on purified mononucleosomes and its individual components, dsDNA and histones. Anti-mononucleosome antibodies can be detected as early as 10 and 23 week of age for MRL lpr/lpr and MP +/+, respectively, and arose before anti-dsDNA and anti-histone antibodies.

摘要

收集30只MRL lpr/lpr小鼠和15只MRL MP +/+小鼠的血清样本，通过酶联免疫吸附测定（ELISA）检测纯化的单核小体及其单个成分双链DNA（dsDNA）和组蛋白。对于MRL lpr/lpr和MP +/+小鼠，分别早在10周龄和23周龄时就能检测到抗单核小体抗体，且其出现早于抗双链DNA抗体和抗组蛋白抗体。

相似文献

1
[The appearance of antinucleosome antibodies precedes that of anti-double-stranded DNA and anti-histones in murine lupus].[在小鼠狼疮中，抗核小体抗体的出现先于抗双链DNA抗体和抗组蛋白抗体]
Rev Med Interne. 1993;14(10):980. doi: 10.1016/s0248-8663(05)80098-0.
2
Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria.在MRL-Mp lpr/lpr和+/+小鼠血清中，核小体限制性抗体在抗双链DNA和/或抗组蛋白抗体之前被检测到，并且存在于有蛋白尿的狼疮小鼠的肾脏洗脱液中。
Arthritis Rheum. 1994 Nov;37(11):1684-8. doi: 10.1002/art.1780371118.
3
Early induction of anti-double-stranded DNA antibodies in lupus-prone MRL mice inoculated with Ly-24+ cells cloned from lymph node cells of an MRL/Mp-lpr/lpr mouse: possible effect of putative cytokines produced by cloned Ly-24+ cells.
Immunol Lett. 1990 Mar-Apr;24(1):49-55. doi: 10.1016/0165-2478(90)90035-o.
4
Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus.系统性红斑狼疮患者中存在核小体限制性抗体。
Arthritis Rheum. 1995 Oct;38(10):1485-91. doi: 10.1002/art.1780381015.
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The emergence of anti-dsDNA antibodies precedes nucleosome-specific antibodies in MRL/lpr and MRL/+ mice.在MRL/lpr和MRL/+小鼠中，抗双链DNA抗体的出现先于核小体特异性抗体。
J Med Dent Sci. 2003 Mar;50(1):9-15.
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Plasma levels of nucleosomes and nucleosome-autoantibody complexes in murine lupus: effects of disease progression and lipopolyssacharide administration.小鼠狼疮中核小体及核小体-自身抗体复合物的血浆水平：疾病进展及脂多糖给药的影响
Arthritis Rheum. 2001 Jun;44(6):1320-30. doi: 10.1002/1529-0131(200106)44:6<1320::AID-ART224>3.0.CO;2-X.
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Involvement in lupus disease of idiotypes Id.F-423 and Id.IV-228 defined, respectively, upon foetal and adult MRL/Mp-lpr/lpr DNA-binding monoclonal autoantibodies.分别基于胎儿和成年MRL/Mp-lpr/lpr DNA结合单克隆自身抗体定义的独特型Id.F-423和Id.IV-228与狼疮疾病的关联。
Immunology. 1991 Oct;74(2):342-7.
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Specificity of monoclonal anti-nucleosome auto-antibodies derived from lupus mice.源自狼疮小鼠的单克隆抗核小体自身抗体的特异性
J Autoimmun. 1996 Dec;9(6):723-9. doi: 10.1006/jaut.1996.0094.
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[Role of the nucleosome in the physiopathology of systemic lupus erythematosus].[核小体在系统性红斑狼疮病理生理学中的作用]
Ann Med Interne (Paris). 2003 Feb;154(1):25-32.
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Effect of histone and histone-RNA complexes on the disease process of murine systemic lupus erythematosus.
Autoimmunity. 1995;21(2):117-22. doi: 10.3109/08916939508993358.

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Time between onset of apoptosis and release of nucleosomes from apoptotic cells: putative implications for systemic lupus erythematosus.细胞凋亡开始至凋亡细胞释放核小体之间的时间：对系统性红斑狼疮的潜在影响。
Ann Rheum Dis. 2003 Jan;62(1):10-4. doi: 10.1136/ard.62.1.10.