[在小鼠狼疮中，抗核小体抗体的出现先于抗双链DNA抗体和抗组蛋白抗体]
[The appearance of antinucleosome antibodies precedes that of anti-double-stranded DNA and anti-histones in murine lupus].
作者信息
Amoura Z, Chabre H, Bach J F, Jacob L
机构信息
Inserm U25, hôpital Necker, Paris.
出版信息
Rev Med Interne. 1993;14(10):980. doi: 10.1016/s0248-8663(05)80098-0.
PMID:8009073
Abstract
Collected samples serum of 30 MRL lpr/lpr and 15 MRL MP +/+ were tested by ELISA on purified mononucleosomes and its individual components, dsDNA and histones. Anti-mononucleosome antibodies can be detected as early as 10 and 23 week of age for MRL lpr/lpr and MP +/+, respectively, and arose before anti-dsDNA and anti-histone antibodies.
摘要
收集30只MRL lpr/lpr小鼠和15只MRL MP +/+小鼠的血清样本，通过酶联免疫吸附测定（ELISA）检测纯化的单核小体及其单个成分双链DNA（dsDNA）和组蛋白。对于MRL lpr/lpr和MP +/+小鼠，分别早在10周龄和23周龄时就能检测到抗单核小体抗体，且其出现早于抗双链DNA抗体和抗组蛋白抗体。
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