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[接种活麻疹疫苗的动物器官中特异性抗原的定位]

[Localization of specific antigen in the organs of animals inoculated with live measles vaccine].

作者信息

Romanov V A, Gorshunova L P, Berezhkova R V

出版信息

Biull Eksp Biol Med. 1976 Oct;82(10):1232-4.

PMID:800956
Abstract

There was a short-lived localization of the antigen of the attenuated measles virus in the neurons and the vessels of the brain in the newborn mice and hamsters inoculated subcutaneously with live measles vaccine. In adult animals the virus specific antigen was revealed in the lymphoid system only. As to the brain tissue of the inoculated animals, the symptoms of serous meningitis and vascular disturbances were observed for a brief period of time. The vaccinal measles virus was not isolated from the brain tissue with the aid of the biotest on tissue culture.

摘要

给新生小鼠和仓鼠皮下接种活麻疹疫苗后,减毒麻疹病毒抗原在其大脑的神经元和血管中有短期定位。在成年动物中,病毒特异性抗原仅在淋巴系统中被发现。至于接种动物的脑组织,在短时间内观察到浆液性脑膜炎和血管紊乱的症状。借助组织培养生物试验,未从脑组织中分离出疫苗性麻疹病毒。

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