Hein H O, Sørensen H, Suadicani P, Gyntelberg F
Rigshospitalet, København.
Ugeskr Laeger. 1994 Feb 28;156(9):1297-302.
In the Copenhagen Male Study we found an increased risk of ischaemic heart disease (IHD) in men with the Lewis phenotype Le(a-b-). This study investigated whether, within the group of Le(a-b-) men, any conventional risk factors modified their increased risk. Three thousand, three hundred and eighty-three men aged 53 to 75 years were examined in 1985/86 and their morbidity and mortality over the next four years recorded. Three hundred and forty-three men with cardiovascular diseases were excluded at baseline. Potential risk factors examined were: alcohol consumption, physical activity, tobacco smoking, serum cotinine, serum lipids, body mass index, blood pressure, hypertension, non-insulin dependent diabetes mellitus and social class. In eligible men with Le(a-b-), N = 280 (9.6%), alcohol was the only risk factor associated with risk of IHD. There was a significant inverse dose-effect relationship between alcohol consumption and risk. The age-adjusted p-values of trend tests were for risk of non-fatal + fatal IHD: p = 0.03; for risk of fatal IHD: p = 0.02. In eligible men with other phenotypes, N = 2,649 (90.4%) only a limited and non-significant negative association with alcohol. In Le(a-b-) men, a group genetically at increased risk of IHD, the risk was strongly and significantly negatively correlated with alcohol consumption.
在哥本哈根男性研究中，我们发现具有Lewis血型Le(a-b-)的男性患缺血性心脏病（IHD）的风险增加。本研究调查了在Le(a-b-)男性群体中，是否有任何传统风险因素会改变他们增加的患病风险。1985/1986年对3383名年龄在53至75岁的男性进行了检查，并记录了他们在接下来四年中的发病率和死亡率。在基线时排除了343名患有心血管疾病的男性。所检查的潜在风险因素包括：饮酒、体育活动、吸烟、血清可替宁、血脂、体重指数、血压、高血压、非胰岛素依赖型糖尿病和社会阶层。在符合条件的Le(a-b-)男性中，N = 280（9.6%），饮酒是与IHD风险相关的唯一风险因素。饮酒量与风险之间存在显著的负剂量效应关系。非致命性+致命性IHD风险趋势检验的年龄调整p值为：p = 0.03；致命性IHD风险的p值为：p = 0.02。在具有其他血型的符合条件的男性中，N = 2649（90.4%），饮酒仅存在有限且不显著的负相关。在Le(a-b-)男性这一遗传上IHD风险增加的群体中，风险与饮酒量呈强烈且显著的负相关。
