[Synthesis and antitumor activity of 4-O-(halogenated) acyl-4'-demethylepipodophyllotoxin analogues].
作者信息
Yin S F, Wang Z G, Ma W Y, Chen X H, Wang T D, Zhang C N
机构信息
Shanghai Institute of Pharmaceutical Industry.
出版信息
Yao Xue Xue Bao. 1993;28(10):758-61.
PMID:8009987
Abstract
A series of 4-(halogenated)acyl-4'-demethylepipodophyllotoxin analogues were conveniently synthesized by selective esterification in the presence of BF3.Et2O, and screened in vitro against L1210 leukemia and KB cells. Most of these compounds showed marked antitumor activity and exhibited more potent activity than that of etoposide.
摘要
Zotero 插件