[Synthesis and antitumor activity of 4-S-(5-amido-1,3,4-thiodiazol-2-yl)4-deoxy-4'-demethylepipodophyllotoxi n analogues].
作者信息
Yin S F, Zhuang W, Ma W Y, Wang Z G, Wang T D, Chen X H, Zhang C N
机构信息
Shanghai Institute of Pharmaceutical Industry.
出版信息
Yao Xue Xue Bao. 1993;28(10):762-5.
PMID:8009988
Abstract
By the condensation of 4'-demethylepipodophyllotoxin with 2-amino-5-mercapto-1,3,4-thiodiazole in CF3COOH and acylation in the presence of DEPC, 10 title compounds were conveniently synthesized. These compounds were screened in vitro against L1210 leukemia and KB cells, in which compounds SIPI-92-1772, 1774, 1775, 1776, 1777 and 1779 exhibited more potent anti-tumor activity.
摘要
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