Zhang M, Huang Y H, Li A, Yang Z C
Department of Pharmacology, Third Military Medical College, Chongqing, China.
Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):529-32.
A rabbit model with severe smoke inhalation injury was used to explore the effects of tetandrine (Tet) on the release of inflammatory mediators and the level of [Ca2+]i in alveolar macrophages (AM) as well as on the ultrastructural changes. It was found that Tet reduced the number of white blood cells (WBC) in bronchoalveolar lavage fluid, inhibited the release of LTB4 and O2-. from AM, and increased the [Ca2+]i in AM. The changes in size, pseudopod, and lysosome evacuation in AM treated with Tet were smaller than those in the AM from the untreated. These results suggest that Tet may alleviate the pulmonary injury through inhibiting the activation of AM.
采用重度烟雾吸入性损伤兔模型，探讨粉防己碱（Tet）对炎症介质释放、肺泡巨噬细胞（AM）内钙离子浓度（[Ca2+]i）及超微结构变化的影响。结果发现，Tet可减少支气管肺泡灌洗液中白细胞（WBC）数量，抑制AM释放白三烯B4（LTB4）和超氧阴离子（O2-），并提高AM内[Ca2+]i。Tet处理的AM在大小、伪足及溶酶体排空方面的变化小于未处理组。这些结果提示，Tet可能通过抑制AM的激活来减轻肺损伤。
