大鼠肝脏线粒体中L-赖氨酸氧化降解的调控
Regulation of oxidative degradation of L-lysine in rat liver mitochondria.
作者信息
Scislowski P W, Foster A R, Fuller M F
机构信息
Rowett Research Institute, Bucksburn, Aberdeen, U.K.
出版信息
Biochem J. 1994 Jun 15;300 ( Pt 3)(Pt 3):887-91. doi: 10.1042/bj3000887.
Abstract
The generation of 14CO2 from [1-14C]lysine by hepatic mitochondria through the saccharopine pathway is controlled by intramitochondrial concentrations of lysine, 2-oxoglutarate and NADPH. Mitochondria, isolated from rats pre-treated with glucagon, exhibited higher activities of L-lysine: 2-oxoglutarate reductase, saccharopine dehydrogenase and 2-aminoadipate aminotransferase. The flux through this pathway is stimulated in liver mitochondria after glucagon treatment. Multiple regulation of lysine oxidation in liver mitochondria confirms a complex mechanism of 'mitochondrial activation' by glucagon.
摘要
肝脏线粒体通过酵母氨酸途径由[1-¹⁴C]赖氨酸生成¹⁴CO₂的过程受线粒体内赖氨酸、2-氧代戊二酸和NADPH浓度的控制。从用胰高血糖素预处理的大鼠中分离出的线粒体，其L-赖氨酸：2-氧代戊二酸还原酶、酵母氨酸脱氢酶和2-氨基己二酸转氨酶的活性较高。胰高血糖素处理后，肝脏线粒体中通过该途径的通量受到刺激。肝脏线粒体中赖氨酸氧化的多重调节证实了胰高血糖素“线粒体激活”的复杂机制。
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