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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Rao V V, Pan X, Chang Y F

Department of Biochemistry, University of Maryland Dental School, Baltimore 21201-1586.

Comp Biochem Physiol B. 1992 Sep;103(1):221-4. doi: 10.1016/0305-0491(92)90435-t.

Developmental aspects of L-lysine-ketoglutarate reductase, the first enzyme in saccharopine pathway of L-lysine degradation in rat liver and brain tissues were studied. 2. Although the adult rat brain shows negligible activity, the enzyme activity was shown to be highly active during the early stages of development. 3. The enzyme activity gradually decreased through development in the brain, whereas it gradually increased in the liver, establishing the fact that the saccharopine pathway is the major pathway in liver. 4. Our results also show that glucagon stimulated the induction of this enzyme by 2-3-fold in both adult liver and brain tissues.

研究了大鼠肝脏和脑组织中L-赖氨酸降解的酵母氨酸途径的第一种酶——L-赖氨酸-酮戊二酸还原酶的发育情况。2. 虽然成年大鼠大脑中的该酶活性可忽略不计，但在发育早期该酶活性表现出高度活跃。3. 该酶活性在大脑发育过程中逐渐降低，而在肝脏中则逐渐升高，这证实了酵母氨酸途径是肝脏中的主要途径这一事实。4. 我们的结果还表明，胰高血糖素在成年肝脏和脑组织中均能使该酶的诱导增加2至3倍。

Rao V V, Pan X, Chang Y F

Department of Biochemistry, University of Maryland Dental School, Baltimore 21201-1586.

Comp Biochem Physiol B. 1992 Sep;103(1):221-4. doi: 10.1016/0305-0491(92)90435-t.

Developmental aspects of L-lysine-ketoglutarate reductase, the first enzyme in saccharopine pathway of L-lysine degradation in rat liver and brain tissues were studied. 2. Although the adult rat brain shows negligible activity, the enzyme activity was shown to be highly active during the early stages of development. 3. The enzyme activity gradually decreased through development in the brain, whereas it gradually increased in the liver, establishing the fact that the saccharopine pathway is the major pathway in liver. 4. Our results also show that glucagon stimulated the induction of this enzyme by 2-3-fold in both adult liver and brain tissues.

研究了大鼠肝脏和脑组织中L-赖氨酸降解的酵母氨酸途径的第一种酶——L-赖氨酸-酮戊二酸还原酶的发育情况。2. 虽然成年大鼠大脑中的该酶活性可忽略不计，但在发育早期该酶活性表现出高度活跃。3. 该酶活性在大脑发育过程中逐渐降低，而在肝脏中则逐渐升高，这证实了酵母氨酸途径是肝脏中的主要途径这一事实。4. 我们的结果还表明，胰高血糖素在成年肝脏和脑组织中均能使该酶的诱导增加2至3倍。