Blarzino C, Coccia R, Pensa B, Cini C, De Marco C
Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università La Sapienza, Roma, Italy.
Biochem Mol Biol Int. 1994 Jan;32(1):79-86.
Selenomethionine is as a good substrate as methionine for bovine liver glutamine transaminase (E.C. 2.6.1.15). Almost identical Km values for methionine, selenomethionine, 4-methylthio-2-oxobutanoic acid and 4-methylseleno-2-oxobutanoic acid have been obtained. Like for other enzymes, also for glutamine transaminase the substitution of the sulfur atom in a substrate molecule by a selenium one does not appreciably affect the enzyme affinity. Glutamine transaminase may thus be involved in selenomethionine catabolism.
