Mahar A F, Allen S J, Milligan P, Suthumnirund S, Chotpitayasunondh T, Sabchareon A, Coulter J B
Liverpool School of Tropical Medicine, England.
Clin Pediatr (Phila). 1994 Apr;33(4):227-31. doi: 10.1177/000992289403300407.
The effectiveness of tepid sponging, in addition to antipyretic medication, in the reduction of temperature in febrile children living in a tropical environment, was assessed in a prospective, randomized, open trial. Seventy-five children aged between 6 and 53 months who attended the casualty department of the Children's Hospital, Bangkok, Thailand, with fever (rectal temperature > or = 38.5 degrees C) of presumed viral origin were randomized to received either tepid sponging and oral paracetamol (sponged group) or paracetamol alone (control group). Rectal temperature and the occurrence of crying, irritability, and shivering were recorded over the following 2 hours. A greater and more rapid fall in mean rectal temperature occurred in the sponged group than in the control group. Temperature fell below 38.5 degrees C sooner in children in the sponged group than in control children (P < 0.001). At 60 minutes, 38 (95.0%) of the controls still had a temperature of 38.5 degrees C or greater, compared with only 15 children (42.9%) in the sponged group (P < 1 x 10(-5). Crying was associated with sponging, but shivering and irritability occurred in only one child who was being sponged. It is concluded that tepid sponging, in addition to antipyretic medication, is clearly more effective than antipyretic medication alone in reducing temperature in febrile children living in a tropical climate.
在一项前瞻性、随机、开放试验中,评估了温水擦浴联合退烧药对生活在热带环境中的发热儿童降温的效果。75名年龄在6至53个月之间、因疑似病毒感染引起发热(直肠温度≥38.5摄氏度)而前往泰国曼谷儿童医院急诊科就诊的儿童被随机分为两组,一组接受温水擦浴和口服对乙酰氨基酚(擦浴组),另一组仅接受对乙酰氨基酚(对照组)。在接下来的2小时内记录直肠温度以及哭闹、烦躁和寒战的发生情况。擦浴组的平均直肠温度下降幅度更大且更快。擦浴组儿童的体温比对照组儿童更快降至38.5摄氏度以下(P<0.001)。60分钟时,对照组中有38名儿童(95.0%)体温仍在38.5摄氏度或以上,而擦浴组中只有15名儿童(42.9%)体温如此(P<1×10⁻⁵)。哭闹与擦浴有关,但寒战和烦躁仅在一名接受擦浴的儿童中出现。结论是,对于生活在热带气候中的发热儿童,温水擦浴联合退烧药在降温方面明显比单独使用退烧药更有效。