Biodistribution of neocarzinostatin conjugated to chimeric Fab fragments of the monoclonal antibody A7 in nude mice bearing human pancreatic cancer xenografts.
作者信息
Otsuji E, Yamaguchi T, Yamaoka N, Taniguchi K, Kato M, Kotani T, Kitamura K, Takahashi T
机构信息
First Department of Surgery, Kyoto Prefectural University of Medicine.
出版信息
Jpn J Cancer Res. 1994 May;85(5):530-5. doi: 10.1111/j.1349-7006.1994.tb02391.x.
Abstract
In this study, we conjugated chimeric Fab fragments of the monoclonal antibody (MAb) A7, which reacts with pancreatic cancers, to the antitumor drug neocarzinostatin (chA7Fab-NCS) and intravenously injected 125I-labeled chA7Fab-NCS into nude mice bearing a human pancreatic cancer xenograft. We compared the tumor localization of 125I-labeled chA7Fab-NCS with that of conventional 125I-labeled A7-NCS, which was produced by conjugation of MAb A7 and NCS. 125I-Labeled chA7Fab-NCS accumulated in the tumor earlier than 125I-labeled A7-NCS, and significantly larger amounts of 125I-labeled chA7Fab-NCS had accumulated in the tumor 1 hour after injection. The results suggest that chA7Fab may be a suitable carrier for NCS in immunotargeting therapy against pancreatic cancer.
摘要
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引用本文的文献
1
Decreased renal accumulation of biotinylated chimeric monoclonal antibody-neocarzinostatin conjugate after administration of avidin.
Jpn J Cancer Res. 1997 Feb;88(2):205-12. doi: 10.1111/j.1349-7006.1997.tb00367.x.
2
Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after administration of avidin.
Br J Cancer. 1996 Aug;74(4):597-602. doi: 10.1038/bjc.1996.407.
3
Effects of neocarzinostatin-chimeric Fab conjugates on the growth of human pancreatic carcinoma xenografts.
Br J Cancer. 1996 May;73(10):1178-82. doi: 10.1038/bjc.1996.227.
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