Rothwell N J, Stock M J
Department of Physiology, St George's Hospital Medical School, London.
Biosci Rep. 1987 Dec;7(12):933-40. doi: 10.1007/BF01122126.
In rats fed a normal (22% protein) diet, injection of clenbuterol (1 mg/kg/d for 21 d) did not affect energy intake, energy expenditure or weight gain, but reduced energetic efficiency, and fat and energy gains and increased body protein content. Presenting a low-protein (8%) diet reduced energy intake, gain and efficiency, body protein content and the mass of the gastrocnemius muscle when compared to rats fed the control diet. Injection of the protein-deficient rats with clenbuterol (1 mg/kg/d for 21 d) caused hypophagia and reduced body weight and energy gains, energy expenditure and total body fat. However, the total body content of protein was not significantly reduced and the percentage of body protein in this protein deficient, clenbuterol-treated group was greater than that of untreated rats on both the high- and low-protein diets. The ratio of body protein to fat following clenbuterol treatment was increased by over 50% in both normal and protein-deficient rats. The results show that in protein deficient animals, clenbuterol treatment may help conserve body protein at the expense of fat, resulting in a smaller, but leaner body mass.
在喂食正常（22%蛋白质）饮食的大鼠中，注射克伦特罗（1毫克/千克/天，持续21天）不影响能量摄入、能量消耗或体重增加，但降低了能量效率、脂肪和能量增加量，并增加了身体蛋白质含量。与喂食对照饮食的大鼠相比，给予低蛋白（8%）饮食会降低能量摄入、增加量和效率、身体蛋白质含量以及腓肠肌质量。给蛋白质缺乏的大鼠注射克伦特罗（1毫克/千克/天，持续21天）会导致摄食减少、体重下降以及能量增加量、能量消耗和全身脂肪减少。然而，全身蛋白质含量并未显著降低，并且在这种蛋白质缺乏且经克伦特罗处理的组中，身体蛋白质百分比高于喂食高蛋白和低蛋白饮食的未处理大鼠。在正常和蛋白质缺乏的大鼠中，克伦特罗处理后身体蛋白质与脂肪的比例均增加了50%以上。结果表明，在蛋白质缺乏的动物中，克伦特罗处理可能有助于以消耗脂肪为代价来保存身体蛋白质，从而导致体重较轻但更瘦的体型。
