Katz M H, Hessol N A, Buchbinder S P, Hirozawa A, O'Malley P, Holmberg S D
Department of Public Health, San Francisco, California 94102-6033.
J Infect Dis. 1994 Jul;170(1):198-202. doi: 10.1093/infdis/170.1.198.
Temporal changes in the lifetime occurrence of opportunistic infections and malignancies among 1115 homosexual men diagnosed with AIDS were examined. Information from the AIDS surveillance registry, hospital pathology and microbiology logs, patient chart reviews, cancer registries, and death certificates was used to calculate the frequency of specific opportunistic infections and malignancies as lifetime (initial or subsequent) diagnoses. The most common lifetime diagnoses were Pneumocystis carinii pneumonia (PCP; 66.5%), Kaposi's sarcoma (KS; 50.7%), disseminated Mycobacterium avium complex (DMAC) infection (29.6%), and cytomegalovirus (CMV) infection (19.6%). From 1981 to 1990, there was a significant decrease in the rate of KS (P = .003) and a significant increase in the rate of DMAC infection (P = .03). PCP decreased during 1985-1990 (P = .009), while CMV infection increased from 1987 through 1990 (P = .03). Thus, KS and PCP have declined over time, while DMAC and CMV are causing substantial and increasing morbidity among AIDS patients.
对1115名被诊断为艾滋病的同性恋男性一生中机会性感染和恶性肿瘤的发生情况进行了时间变化研究。利用艾滋病监测登记处、医院病理和微生物学记录、患者病历审查、癌症登记处以及死亡证明等信息，计算特定机会性感染和恶性肿瘤作为终生（初次或后续）诊断的频率。最常见的终生诊断为卡氏肺孢子虫肺炎（PCP；66.5%）、卡波西肉瘤（KS；50.7%）、播散性鸟分枝杆菌复合体（DMAC）感染（29.6%）和巨细胞病毒（CMV）感染（19.6%）。从1981年到1990年，KS的发病率显著下降（P = .003），DMAC感染的发病率显著上升（P = .03）。PCP在1985 - 1990年期间下降（P = .009），而CMV感染从1987年到1990年增加（P = .03）。因此，随着时间的推移，KS和PCP有所下降，而DMAC和CMV在艾滋病患者中导致的发病率大幅上升且呈上升趋势。
