Castelo-Branco C, Pons F, Gratacós E, Fortuny A, Vanrell J A, González-Merlo J
Department of Gynaecology and Obstetrics, Hospital Clinic i Provincial de Barcelona, School of Medicine, University of Barcelona, Spain.
Maturitas. 1994 Mar;18(3):199-206. doi: 10.1016/0378-5122(94)90126-0.
There is evidence that skin collagen content and bone mass are influenced by estrogen deficiency, both of them declining in the years following menopause. The aim of our study was to analyze the relationship between changes in skin collagen content and bone mass during aging. A total of 76 nulliparous women who had been admitted for surgery of non-malignant processes were studied. All subjects were arranged into five age-groups (from 20 to 60 years). Bone mineral density was measured by dual photon absorptiometry and expressed in g/cm2 as the mean of the second to fourth lumbar vertebrae. Additionally, in all patients skin biopsies were taken from a non-sun exposed site in the lower abdomen (4 cm above the pubic symphysis) and osteocalcin levels were determined. Collagen decreased significantly with age after the 40s (P < 0.001) and after menopause (P < 0.001). Changes in bone mass were closely related to those detected in collagen (r = 0.586; P < 0.0001). In conclusion, our data suggest that bone mass and skin collagen decline in parallel with aging and that the hypoestrogenism developing in postmenopausal years has a significant effect on skin collagen content. Nevertheless, the question of whether osteoporosis is an intrinsic collagen disorder remains to be demonstrated.
有证据表明，皮肤胶原蛋白含量和骨量受雌激素缺乏的影响，在绝经后的几年里二者均会下降。我们研究的目的是分析衰老过程中皮肤胶原蛋白含量变化与骨量之间的关系。共研究了76名因非恶性疾病接受手术的未生育女性。所有受试者被分为五个年龄组（20至60岁）。采用双能光子吸收法测量骨矿物质密度，并以第二至第四腰椎的平均值表示，单位为g/cm²。此外，对所有患者在下腹部非阳光暴露部位（耻骨联合上方4 cm）进行皮肤活检，并测定骨钙素水平。40岁以后（P < 0.001）和绝经后（P < 0.001），胶原蛋白随年龄显著下降。骨量变化与胶原蛋白检测结果密切相关（r = 0.586；P < 0.0001）。总之，我们的数据表明，骨量和皮肤胶原蛋白随衰老而平行下降，绝经后出现的雌激素缺乏对皮肤胶原蛋白含量有显著影响。然而，骨质疏松症是否为一种内在的胶原蛋白疾病仍有待证实。
