聚（ADP-核糖）聚合酶：一种分子切口传感器。

Poly(ADP-ribose) polymerase: a molecular nick-sensor.

作者信息

de Murcia G, Ménissier de Murcia J

机构信息

Institut de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique, Unité de Cancérogénèse et Mutagénèse Moléculaire et Structurale, Strasbourg, France.

出版信息

Trends Biochem Sci. 1994 Apr;19(4):172-6. doi: 10.1016/0968-0004(94)90280-1.

DOI:10.1016/0968-0004(94)90280-1

PMID:8016868

Abstract

Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genotoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and function of this abundant and highly conserved enzyme.

摘要

聚（ADP-核糖）聚合酶（PARP）参与真核细胞构建的复杂系统网络，以应对众多环境和内源性基因毒性因子。PARP基因的克隆使得人们能够采用遗传学和分子学方法来阐明这种丰富且高度保守的酶的结构与功能。