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Structure and function of poly(ADP-ribose) polymerase.

作者信息

de Murcia G, Schreiber V, Molinete M, Saulier B, Poch O, Masson M, Niedergang C, Ménissier de Murcia J

机构信息

Ecole Supérieure de Biotechnologie de Strasbourg, Unité de Cancérogénèse et de Mutagénèse Moléculaire et Structurale, Centre National de la Recherche Scientifique, Illkirch-Graffenstaden, France.

出版信息

Mol Cell Biochem. 1994 Sep;138(1-2):15-24. doi: 10.1007/BF00928438.

DOI:10.1007/BF00928438
PMID:7898458
Abstract

Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genetoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and the function of this abundant and highly conserved enzyme. This article summarizes our present knowledge in this field.

摘要

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本文引用的文献

1
Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.聚（ADP - 核糖）聚合酶DNA结合域的过度产生会阻碍哺乳动物细胞中烷基化诱导的DNA修复合成。
EMBO J. 1993 May;12(5):2109-17. doi: 10.1002/j.1460-2075.1993.tb05859.x.
2
Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain.果蝇聚（ADP - 核糖）聚合酶编码cDNA的克隆：自身修饰结构域中的亮氨酸拉链
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3481-5. doi: 10.1073/pnas.90.8.3481.
3
Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role.
在蛭形轮虫阿迪内塔vag中，电离辐射反应似乎是脱水反应的附带现象。
BMC Biol. 2024 Jan 25;22(1):11. doi: 10.1186/s12915-023-01807-8.
4
Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment.糖尿病周围神经病变：发病机制与治疗。
Front Endocrinol (Lausanne). 2024 Jan 9;14:1265372. doi: 10.3389/fendo.2023.1265372. eCollection 2023.
5
Kidney function in patients with ovarian cancer treated with poly (ADP-ribose) polymerase (PARP) inhibitors.卵巢癌患者接受聚（ADP-核糖）聚合酶（PARP）抑制剂治疗后的肾功能。
J Natl Cancer Inst. 2023 Jul 6;115(7):831-837. doi: 10.1093/jnci/djad070.
6
Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence.烟酰胺单核苷酸通过抑制肾小管DNA损伤和衰老减轻急性肾损伤后的肾间质纤维化。
Front Physiol. 2021 Mar 23;12:649547. doi: 10.3389/fphys.2021.649547. eCollection 2021.
7
Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.聚（ADP-核糖）聚合酶-1（PARP-1）的高清调节亚结构域的动力学；PARP激活和抑制中的底物可及性与变构效应
Nucleic Acids Res. 2021 Feb 26;49(4):2266-2288. doi: 10.1093/nar/gkab020.
8
The Multifactorial Role of PARP-1 in Tumor Microenvironment.聚（ADP-核糖）聚合酶-1（PARP-1）在肿瘤微环境中的多因素作用
Cancers (Basel). 2020 Mar 20;12(3):739. doi: 10.3390/cancers12030739.
9
Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent.活性氧/氮物种对NAD降低剂APO866的抗白血病作用有显著贡献。
Oncotarget. 2019 Nov 19;10(62):6723-6738. doi: 10.18632/oncotarget.27336.
10
Targeting ADP-ribosylation as an antimicrobial strategy.靶向 ADP-ribosylation 作为一种抗菌策略。
Biochem Pharmacol. 2019 Sep;167:13-26. doi: 10.1016/j.bcp.2019.06.001. Epub 2019 Jun 6.
大肠杆菌的Fpg蛋白是一种锌指蛋白，其半胱氨酸残基具有结构和/或功能作用。
J Biol Chem. 1993 Apr 25;268(12):9063-70.
4
Identification of potential active-site residues in the human poly(ADP-ribose) polymerase.人多聚（ADP - 核糖）聚合酶中潜在活性位点残基的鉴定
J Biol Chem. 1993 Apr 25;268(12):8529-35.
5
The carboxyl-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli, large scale purification, and characterization.人聚（ADP-核糖）聚合酶的羧基末端结构域。在大肠杆菌中的过量表达、大规模纯化及特性鉴定。
J Biol Chem. 1993 Jun 25;268(18):13454-61.
6
Conformational analysis of a 139 base-pair DNA fragment containing a single-stranded break and its interaction with human poly(ADP-ribose) polymerase.包含单链断裂的139个碱基对DNA片段的构象分析及其与人聚（ADP - 核糖）聚合酶的相互作用。
J Mol Biol. 1994 Jan 21;235(3):1062-71. doi: 10.1006/jmbi.1994.1057.
7
Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure.多聚核小体的聚（ADP - 核糖基）化导致染色质结构松弛。
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3423-7. doi: 10.1073/pnas.79.11.3423.
8
Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.聚（ADP - 核糖）合成酶。三种蛋白水解片段作为底物结合结构域、DNA结合结构域和自身修饰结构域的分离与鉴定。
J Biol Chem. 1984 Apr 25;259(8):4770-6.
9
Poly(ADP-ribose) polymerase auto-modification and interaction with DNA: electron microscopic visualization.聚（ADP - 核糖）聚合酶的自身修饰及其与DNA的相互作用：电子显微镜观察
EMBO J. 1983;2(4):543-8. doi: 10.1002/j.1460-2075.1983.tb01460.x.
10
Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks.受损DNA体外编程的聚（ADP - 核糖）合成。含有不同类型链断裂的DNA分子的比较。
J Biol Chem. 1980 Nov 10;255(21):10502-8.