Wabitsch M, Hauner H, Heinze E, Muche R, Böckmann A, Parthon W, Mayer H, Teller W
Department of Pediatrics, University of Ulm, Germany.
Am J Clin Nutr. 1994 Jul;60(1):54-60. doi: 10.1093/ajcn/60.1.54.
We examined the effect of the pattern of body-fat distribution on the modification of atherogenic risk factors in obese adolescent girls during weight reduction. During the 6-wk program, which included a mixed diet of 4321 kJ/d and intensive physical exercise, the girls lost 8.5 +/- 2.4 kg and their waist-to-hip ratio (WHR) decreased from 0.86 +/- 0.05 to 0.81 +/- 0.05 (P < 0.01). Significant reductions were observed for total cholesterol, LDL cholesterol, uric acid, fasting insulin, and systolic and diastolic blood pressure. Girls with abdominal obesity (WHR > 0.88) had greater reductions in serum cholesterol, LDL cholesterol, and uric acid than did girls with gluteal-femoral obesity (WHR < 0.81). In a multivariate-regression analysis these differences could be partly explained by the greater weight loss of the girls with abdominal obesity. These results suggest that during weight reduction girls with abdominal obesity exhibit more beneficial changes in the atherogenic-risk-factor profile than do girls with gluteal-femoral obesity, partly because of a greater weight loss.
我们研究了肥胖青春期女孩在减肥过程中体脂分布模式对致动脉粥样硬化风险因素改善情况的影响。在为期6周的项目中，该项目包括每日4321千焦的混合饮食和强化体育锻炼，这些女孩体重减轻了8.5±2.4千克，腰臀比（WHR）从0.86±0.05降至0.81±0.05（P<0.01）。总胆固醇、低密度脂蛋白胆固醇、尿酸、空腹胰岛素以及收缩压和舒张压均显著降低。腹部肥胖（WHR>0.88）的女孩血清胆固醇、低密度脂蛋白胆固醇和尿酸的降低幅度大于臀股部肥胖（WHR<0.81）的女孩。在多变量回归分析中，这些差异部分可由腹部肥胖女孩更大的体重减轻来解释。这些结果表明，在减肥过程中，腹部肥胖的女孩比臀股部肥胖的女孩在致动脉粥样硬化风险因素方面表现出更有益的变化，部分原因是体重减轻更多。
