Wilson A, Hickie I, Lloyd A, Wakefield D
Department of Psychiatry, Prince Henry Hospital, Little Bay NSW, Australia.
Am J Med. 1994 Jun;96(6):544-50. doi: 10.1016/0002-9343(94)90095-7.
The chronic fatigue syndrome (CFS) is a heterogeneous disorder characterized by fatigue, neuropsychiatric symptoms, and various other somatic complaints. Treatment studies to date reflect both the diversity of medical disciplines involved in the management of patients with CFS and the multiple pathophysiologic mechanisms proposed. There have been few attempts to study integrated treatment programs, and although several controlled studies have been reported, no treatment has been shown clearly to result in long-term benefit in the majority of patients. Good clinical care integrating medical and psychologic concepts, together with symptomatic management, may prevent significant secondary impairment in the majority of patients. Future treatment studies should examine differential response rates for possible subtypes of the disorder (eg, documented viral onset, concurrent clinical depression), evaluate the extent of any synergistic effects between therapies (ie, medical and psychologic), and employ a wide range of biologic and psychologic parameters as markers of treatment response.
慢性疲劳综合征（CFS）是一种异质性疾病，其特征为疲劳、神经精神症状以及各种其他躯体不适。迄今为止的治疗研究既反映了参与CFS患者管理的医学学科的多样性，也反映了所提出的多种病理生理机制。很少有人尝试研究综合治疗方案，尽管已经报道了几项对照研究，但尚无一种治疗方法能明确显示对大多数患者有长期益处。将医学和心理学概念与症状管理相结合的良好临床护理，可能会防止大多数患者出现严重的继发性损害。未来的治疗研究应检查该疾病可能的亚型（例如，有记录的病毒发作、并发临床抑郁症）的差异反应率，评估治疗（即医学和心理学治疗）之间任何协同效应的程度，并采用广泛的生物学和心理学参数作为治疗反应的标志物。
