Naumann A, Bujía J, Hammer C, Wilmes E
Klinik und Poliklinik für Hals-Nasen-Ohren-Krankheiten, Ludwig-Maximilians-Universität München.
Laryngorhinootologie. 1994 May;73(5):253-7. doi: 10.1055/s-2007-997124.
The clinical relevance of antibodies against components of cartilage in the reconstructive surgery has not yet been clarified. In our study four groups of patients with successful and unsuccessful autologous cartilage transplantation in rhinosurgery, patients with ear perichondritis and patients with tracheal stenosis after long-term intubation were investigated for the presence of a humoral immune reactivity to cartilage. The control groups consisted of healthy persons and patients with RA. The antibodies against cartilage matrix and chondrocytes were determined using indirect immunofluorescence methods. Patients with unsuccessful cartilage transplantation showed increased antibodies against autologous cartilage (until 1:100) compared to the patients with successful cartilage transplantation. Furthermore, patients suffering from ear perichondritis and tracheal stenosis showed also increased antibodies against cartilage. These data suggest that a humoral immune reactivity against autologous cartilage--independent of an infection--can be one cause for the destruction of cartilaginous tissue.
在重建手术中，针对软骨成分的抗体的临床相关性尚未明确。在我们的研究中，对四组患者进行了调查，包括鼻外科自体软骨移植成功和失败的患者、耳部软骨膜炎患者以及长期插管后气管狭窄的患者，以检测其对软骨的体液免疫反应性。对照组由健康人和类风湿性关节炎患者组成。使用间接免疫荧光法测定针对软骨基质和软骨细胞的抗体。与软骨移植成功的患者相比，软骨移植失败的患者显示出针对自体软骨的抗体增加（高达1:100）。此外，耳部软骨膜炎和气管狭窄患者也显示出针对软骨的抗体增加。这些数据表明，针对自体软骨的体液免疫反应性——与感染无关——可能是软骨组织破坏的一个原因。
