Schwarz R, Krüll A, Heyer D, Baumann M, Schmidt R, Hübener K H
Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Germany.
Acta Oncol. 1994;33(3):281-7. doi: 10.3109/02841869409098418.
Results of fast neutron therapy are reviewed with special reference to the main indications for this type of treatment and the experience of five German centers. Neutron therapy seems beneficial compared to conventional radiotherapy in advanced salivary gland tumors, inoperable or unresectable soft tissue sarcomas, some bone tumors, prostate cancer stage C and some rare low-grade tumors. About 3,000 patients with malignancies have been treated with neutrons at the German centers Berlin/Rossendorf, Essen, Hamburg, Heidelberg and Münster. Treatment results and treatment-related morbidity depend on the treatment techniques and the physical selectivity of the neutron machines. A critical appraisal suggests that fast neutrons are of advantage in about 5% of all radiotherapy patients.
本文回顾了快中子治疗的结果，特别提及了这种治疗方式的主要适应症以及五个德国中心的经验。与传统放疗相比，快中子治疗在晚期涎腺肿瘤、无法手术或不可切除的软组织肉瘤、某些骨肿瘤、C期前列腺癌以及一些罕见的低级别肿瘤中似乎更具优势。德国柏林/罗森多夫、埃森、汉堡、海德堡和明斯特的这些中心已经用中子治疗了约3000例恶性肿瘤患者。治疗结果和与治疗相关的发病率取决于治疗技术和中子治疗设备的物理选择性。一项批判性评估表明，快中子在所有放疗患者中约占5%的优势。
